中山大学附属第五医院:新冠病毒感染者的胃肠道症状
创作:王文东 审核:aluba 2020年04月10日
  • 纳入95名SARS-CoV-2感染者,58例出现胃肠道(GI)症状,有GI症状与无GI症状患者的临床预后无明显差异;
  • 腹泻、厌食和恶心为主要GI症状,住院期间使用的多种药物(包括抗生素)可能加剧腹泻;
  • 42例GI症状和23例无GI症状患者中,分别在22例和9例患者的粪便中检出SARS-CoV-2;
  • 6例GI症状患者进行内镜检查,1例重症患者食管出血伴糜烂和溃疡,2例重症患者食管、胃、十二指肠和直肠中均检出SARS-CoV-2,4例非重症患者中仅1例十二指肠阳性。
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来自中山大学附属第五医院的Hong Shang团队、Xiaofeng Li团队及Zhixiang Yan团队在Gut上发表的一项最新研究,报道了95名新冠病毒感染者中出现的胃肠道症状,发现腹泻、厌食及恶心为新冠病毒感染后发生的主要胃肠道症状,且在无胃肠道症状的患者中,也可在粪便中检出病毒。
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Gut [IF:23.059]

Gastrointestinal symptoms of 95 cases with SARS-CoV-2 infection

95例SARS-CoV-2感染者的胃肠道症状

10.1136/gutjnl-2020-321013

2020-04-02, Article

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Objective : To study the GI symptoms in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infected patients.
Design : We analysed epidemiological, demographic, clinical and laboratory data of 95 cases with SARS-CoV-2 caused coronavirus disease 2019. Real-time reverse transcriptase PCR was used to detect the presence of SARS-CoV-2 in faeces and GI tissues.
Results : Among the 95 patients, 58 cases exhibited GI symptoms of which 11 (11.6%) occurred on admission and 47 (49.5%) developed during hospitalisation. Diarrhoea (24.2%), anorexia (17.9%) and nausea (17.9%) were the main symptoms with five (5.3%), five (5.3%) and three (3.2%) cases occurred on the illness onset, respectively. A substantial proportion of patients developed diarrhoea during hospitalisation, potentially aggravated by various drugs including antibiotics. Faecal samples of 65 hospitalised patients were tested for the presence of SARS-CoV-2, including 42 with and 23 without GI symptoms, of which 22 (52.4%) and 9 (39.1%) were positive, respectively. Six patients with GI symptoms were subjected to endoscopy, revealing oesophageal bleeding with erosions and ulcers in one severe patient. SARS-CoV-2 RNA was detected in oesophagus, stomach, duodenum and rectum specimens for both two severe patients. In contrast, only duodenum was positive in one of the four non-severe patients.
Conclusions: GI tract may be a potential transmission route and target organ of SARS-CoV-2.

First Authors:
Lu Lin,Xiayang Jiang

Correspondence Authors:
Zhixiang Yan,Xiaofeng Li,Hong Shan

All Authors:
Lu Lin,Xiayang Jiang,Zhenling Zhang,Siwen Huang,Zhenyi Zhang,Zhaoxiong Fang,Zhiqiang Gu,Liangqing Gao,Honggang Shi,Lei Mai,Yuan Liu,Xianqi Lin,Renxu Lai,Zhixiang Yan,Xiaofeng Li,Hong Shan

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