张宏福+陈亮+尹杰:肠道菌群如何调节食欲(综述)
创作:徐硕 审核:mildbreeze 2021年09月01日
  • 食欲的生理控制是由外周器官产生的促进和抑制食欲的激素(如瘦素、胃饥饿素、胰岛素等)介导,肠道菌群可影响这类激素的组成和作用;
  • 肠道菌群代谢产物和成分(SCFA、琥珀酸、色氨酸代谢物、GABA、BCAA、胆汁酸等)可调节激素分泌和免疫系统以及直接作用于下丘脑神经元,以影响食欲;
  • 肠道菌群蛋白ClpB可作为α-黑素细胞刺激素模拟物,通过直接或间接机制来抑制食欲;
  • 调控肠道菌群在改善食欲相关疾病上具有临床应用潜力。
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mildbreeze
中国农业科学院张宏福、陈亮和湖南农业大学尹杰与团队,近期在Microbiome发表综述,介绍了肠道菌群(特别是其代谢产物)对宿主食欲的调控作用和机制,并对其临床应用前景进行了展望,推荐专业人士关注。
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Microbiome [IF:16.837]

From gut microbiota to host appetite: gut microbiota-derived metabolites as key regulators

从肠道菌群到宿主食欲:肠道菌群衍生代谢物作为关键调节剂

10.1186/s40168-021-01093-y

2021-07-20, Review

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Feelings of hunger and satiety are the key determinants for maintaining the life of humans and animals. Disturbed appetite control may disrupt the metabolic health of the host and cause various metabolic disorders. A variety of factors have been implicated in appetite control, including gut microbiota, which develop the intricate interactions to manipulate the metabolic requirements and hedonic feelings. Gut microbial metabolites and components act as appetite-related signaling molecules to regulate appetite-related hormone secretion and the immune system, or act directly on hypothalamic neurons. Herein, we summarize the effects of gut microbiota on host appetite and consider the potential molecular mechanisms. Furthermore, we propose that the manipulation of gut microbiota represents a clinical therapeutic potential for lessening the development and consequence of appetite-related disorders. Video abstract.

First Authors:
Hui Han,Bao Yi

Correspondence Authors:
Jie Yin,Liang Chen,Hongfu Zhang

All Authors:
Hui Han,Bao Yi,Ruqing Zhong,Mengyu Wang,Shunfen Zhang,Jie Ma,Yulong Yin,Jie Yin,Liang Chen,Hongfu Zhang

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