张发明等:菌群移植疗法的概念、方法和策略(综述)
  • 粪菌移植(FMT)是医疗研究的新热点,治疗艰难梭菌感染和炎症性肠病等疾病的临床试验初有成效;
  • 中医使用粪菌治病历史悠久,现代FMT类似疗法还有益生菌和选择性菌群移植(SMT),菌群移植还可用于其它身体部位;
  • 为最大化FMT的疗效和安全性,应注意粪菌材料的制备、保存和质量控制,推荐使用新鲜材料进行移植(有成熟的操作流程),选用适当的输送方式,严格筛选粪菌供体,综合使用FMT升阶治疗策略;
  • SMT和FMT或可用于癌症治疗。
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mildbreeze
Protein & Cell中国肠道大会专刊发布由南京医科大学第二附属医院张发明主笔的菌群移植综述,介绍了粪菌移植的历史、概念和方法变迁、FMT升阶治疗策略、操作流程相关问题和注意事项等方面。粪菌移植和选择性菌群移植用于疾病治疗,前景广阔,推荐专业人士关注。
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Protein & Cell [IF:15.328]

Microbiota transplantation: concept, methodology and strategy for its modernization

菌群移植:其现代化的概念,方法和策略

10.1007/s13238-018-0541-8

2018-04-24, Review

Abstract & Authors:展开

Abstract:收起
Fecal microbiota transplantation (FMT) has become a research focus of biomedicine and clinical medicine in recent years. The clinical response from FMT for different diseases provided evidence for microbiota-host interactions associated with various disorders, including Clostridium difficile infection, inflammatory bowel disease, diabetes mellitus, cancer, liver cirrhosis, gut-brain disease and others. To discuss the experiences of using microbes to treat human diseases from ancient China to current era should be important in moving standardized FMT forward and achieving a better future. Here, we review the changing concept of microbiota transplantation from FMT to selective microbiota transplantation, methodology development of FMT and step-up FMT strategy based on literature and state experts' perspectives.

First Authors:
Faming Zhang

Correspondence Authors:
Faming Zhang

All Authors:
Faming Zhang,Bota Cui,Xingxiang He,Yuqiang Nie,Kaichun Wu,Daiming Fan,FMT-standardization Study Group

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