谢鹏+王刚+胡少华:绘制重度抑郁症的肠道生态系统图谱
  • 分析重度抑郁症患者(MDD,311位)和健康对照(HC)的肠道病毒组、肠道细菌组和粪便代谢组,鉴定出3种噬菌体、47种细菌和50种粪便代谢物的丰度在两者之间具有显著差异;
  • MDD的主要特征是拟杆菌属的丰度增加,而劳特氏菌和真细菌属的丰度减少;
  • 多层次的组学改变产生了一个典型的MDD共表达网络;
  • 受干扰的微生物基因和粪便代谢物都与γ-氨基丁酸盐、苯丙氨酸和色氨酸等氨基酸代谢有关;
  • 鉴定出一个组合性标志物可用于区分MDD和HC。
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章台柳
重庆医科大学第一附属医院谢鹏、首都医科大学北京安定医院王刚和浙江大学医学院第一附属医院胡少华合作在Science Advances上发表文章,利用全基因组鸟枪法宏基因组和非靶向代谢组学的方法对重度抑郁症患者(MDD)和健康对照(HC)进行肠道病毒、细菌和粪便代谢物的分析,鉴定出两者之间的差异特征,并形成一个组合性鉴定标志物可区分MDD和HC。此外,MDD中受干扰的微生物基因和粪便代谢物都与氨基酸代谢相关。研究加深了我们对肠道生态系统在MDD病理中作用的理解。
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Science Advances [IF:14.957]

Landscapes of bacterial and metabolic signatures and their interaction in major depressive disorders

重度抑郁症患者的肠道细菌、代谢特征及其互作图谱

10.1126/sciadv.aba8555

2020-12-02, Article

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Gut microbiome disturbances have been implicated in major depressive disorder (MDD). However, little is known about how the gut virome, microbiome, and fecal metabolome change, and how they interact in MDD. Here, using whole-genome shotgun metagenomic and untargeted metabolomic methods, we identified 3 bacteriophages, 47 bacterial species, and 50 fecal metabolites showing notable differences in abundance between MDD patients and healthy controls (HCs). Patients with MDD were mainly characterized by increased abundance of the genus Bacteroides and decreased abundance of the genera Blautia and Eubacterium. These multilevel omics alterations generated a characteristic MDD coexpression network. Disturbed microbial genes and fecal metabolites were consistently mapped to amino acid (γ-aminobutyrate, phenylalanine, and tryptophan) metabolism. Furthermore, we identified a combinatorial marker panel that robustly discriminated MDD from HC individuals in both the discovery and validation sets. Our findings provide a deep insight into understanding of the roles of disturbed gut ecosystem in MDD.

First Authors:
Jian Yang,Peng Zheng

Correspondence Authors:
Shaohua Hu,Gang Wang,Peng Xie

All Authors:
Jian Yang,Peng Zheng,Yifan Li,Jing Wu,Xunmin Tan,Jingjing Zhou,Zuoli Sun,Xu Chen,Guofu Zhang,Hanping Zhang,Yu Huang,Tingjia Chai,Jiajia Duan,Weiwei Liang,Bangmin Yin,Jianbo Lai,Tingting Huang,Yanli Du,Peifen Zhang,Jiajun Jiang,Caixi Xi,Lingling Wu,Jing Lu,Tingting Mou,Yi Xu,Seth W Perry,Ma-Li Wong,Julio Licinio,Shaohua Hu,Gang Wang,Peng Xie

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