• 清华程功团队的研究成果,描述了昆虫共生微生物组抵消肠道免疫以实现体内平衡的机制;
  • 研究发现蚊子的肠道菌群利用C类凝集素来逃脱抗菌肽杀菌作用;
  • 埃及伊蚊的C类凝集素促进共生菌在蚊子肠道的定殖,在另外一种蚊子中沉默C类凝集素同源基因的表达使肠道菌群的存活率受损;
  • 蚊子的肠道菌群可刺激C类凝集素的表达,而C类凝集素覆盖在细菌表面防止抗菌肽对细菌的作用。
Nature Microbiology [IF:17.745]

Mosquito C-type lectins maintain gut microbiome homeostasis



2016-03-14, Article

Abstract & Authors:展开

The long-term evolutionary interaction between the host immune system and symbiotic bacteria determines their cooperative rather than antagonistic relationship. It is known that commensal bacteria have evolved a number of mechanisms to manipulate the mammalian host immune system and maintain homeostasis. However, the strategies employed by the microbiome to overcome host immune responses in invertebrates still remain to be understood. Here, we report that the gut microbiome in mosquitoes utilizes C-type lectins (mosGCTLs) to evade the bactericidal capacity of antimicrobial peptides (AMPs). Aedes aegypti mosGCTLs facilitate colonization by multiple bacterial strains. Furthermore, maintenance of the gut microbial flora relies on the expression of mosGCTLs in A. aegypti. Silencing the orthologues of mosGCTL in another major mosquito vector (Culex pipiens pallens) also impairs the survival of gut commensal bacteria. The gut microbiome stimulates the expression of mosGCTLs, which coat the bacterial surface and counteract AMP activity. Our study describes a mechanism by which the insect symbiotic microbiome offsets gut immunity to achieve homeostasis.

First Authors:
Xiaojing Pang

Correspondence Authors:
Gong Cheng

All Authors:
Xiaojing Pang,Xiaoping Xiao,Yang Liu,Rudian Zhang,Jianying Liu,Qiyong Liu,Penghua Wang,Gong Cheng