清华程功团队:蚊媒病毒的传播受哪些肠道内外的影响(综述)
  • 蚊媒病毒主要感染脊椎动物,是人类疾病的致病因子之一,在蚊子和宿主之间传播;
  • 蚊咬后释放的唾液成分,可通过调控宿主免疫应答、增强病毒黏附、诱导细胞迁移、调节宿主血管通透性等方式,帮助虫媒病毒传播;
  • 宿主血液组分可调控蚊子肠道免疫和生理状态,影响蚊媒病毒的定植,如GABA和NS1起促进作用,而IgM、IgG、LDL和血清铁有抑制作用;
  • 蚊子的肠道相关因子如细菌和真菌组成、抗病毒固有免疫途径和肠道屏障,也调控病毒的获得。
主编推荐语
mildbreeze
蚊媒病毒在蚊子和脊椎动物宿主之间传播,循环往复,是很多人类传染病的致病因子。Trends in Parasitology近期发表了清华大学程功团队的综述,总结了影响蚊媒病毒的传播和获得的因素,包括蚊子肠道和宿主相关因子,值得专业人士关注。
关键字
延伸阅读本研究的原文信息和链接出处,以及相关解读和评论文章。欢迎读者朋友们推荐!

Progress towards Understanding the Mosquito-Borne Virus Life Cycle

蚊媒病毒生命周期的研究进展

10.1016/j.pt.2019.09.006

2019-10-25, Review

Abstract & Authors:展开

Abstract:收起
Mosquito-borne arboviruses are a group of heterogeneous viruses that are mainly transmitted to vertebrate hosts and are the aetiological agents of many human diseases. These viruses naturally maintain a life cycle between distinct hosts by transmission from an infected mosquito to a naive host, and acquisition from a viraemic host back to a fed mosquito. To survive in and maintain a cycle between different host environments, mosquito-borne arboviruses exploit sophisticated approaches, including subverting the immune system, hijacking host factors, and taking advantage of gut microbes. We summarize the recent progress towards understanding the mechanisms of arboviral transmission and acquisition by mosquitoes. This knowledge offers an insight into the emergence and re-emergence of arboviruses in nature and an avenue for disease prevention in the future.

First Authors:
Xi Yu,Yibin Zhu,Xiaoping Xiao

Correspondence Authors:
Gong Cheng

All Authors:
Xi Yu,Yibin Zhu,Xiaoping Xiao,Penghua Wang,Gong Cheng

评论