中国航天员中心:航天飞行对肠道菌群的影响
  • 在2次航天飞行任务中,收集5名航天员执行任务前后的粪便样本,对航天飞行中肠道菌群的波动进行分析;
  • 航天飞行对肠道菌群的组成及功能产生显著影响,抗生素的生物合成功能发生显著变化,且菌属丰富度降低;
  • 航天飞行对耐药基因的总数无显著影响,对一些抗生素耐药基因和可移动遗传原件有所影响;
  • 航天飞行后,肠道菌群中的毒力基因总数增加,有害细菌的毒力和感染机会增加;
  • 在未来的航天飞行中应该考虑航天员的肠道菌群变化。
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来自中国航天员科研训练中心的Yingxian Li与Shukuan Ling团队在Gut Microbes上发表的一项最新研究,对执行2次航天飞行任务(分别为15天及35天)的5名航天员在执行飞行任务前后的肠道菌群进行对比分析,鉴定出了航天飞行对肠道菌群多样性、组成、功能、耐药基因、毒力基因的影响,提示在未来的航天飞行中应该考虑航天员的肠道菌群变化。
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Gut Microbes [IF:10.245]

Effects of spaceflight on the composition and function of the human gut microbiota

航天飞行对人体肠道菌群组成和功能的影响

10.1080/19490976.2019.1710091

2020-01-10, Report

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Interaction between humans and the gut microbiota is important for human physiology. Here, the gut microbiota was analyzed via metagenomic sequencing, and the fluctuations in the gut microbiota under the conditions of spaceflight were characterized. The composition and function of the gut microbiota were substantially affected by spaceflight; however, individual specificity was uncompromised. We further confirmed the species fluctuations and functional genes from both missions. Resistance and virulence genes in the gut microbiota were affected by spaceflight, but the species attributions remained stable. Spaceflight markedly affected the composition and function of the human gut microbiota, implying that the human gut microbiota is sensitive to spaceflight.

First Authors:
Zizhong Liu

Correspondence Authors:
Shukuan Ling,Yingxian Li

All Authors:
Zizhong Liu,Gui Luo,Ruikai Du,Weijia Sun,Jianwei Li,Haiyun Lan,Pu Chen,Xinxin Yuan,Dengchao Cao,Yuheng Li,Caizhi Liu,Shuai Liang,Xiaoyan Jin,Ruifu Yang,Yujing Bi,Yanping Han,Ping Cao,Wei Zhao,Shukuan Ling,Yingxian Li

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