用健康蛋白代替动物蛋白,或可降低心血管疾病发病率及全因死亡率
创作:aluba 审核:aluba 2021年01月17日
  • 纳入6项前瞻性队列研究中的29,682名美国受试者的数据,分析将动物蛋白食物替换为植物蛋白食物或其它动物蛋白食物,对心血管疾病发病率及全因死亡率的影响;
  • 用坚果、全谷物、豆类或鱼,替代蛋、加工肉类、未加工红肉或猪肉,与心血管疾病发病率及全因死亡率的降低相关;
  • 每天将上述4种食物(蛋、加工肉类、未加工红肉或猪肉,各一份或更多)替换为另外4种食物,可降低54%的心血管疾病发病率及30%的全因死亡率。
主编推荐语
aluba
International Journal of Epidemiology上发表的一项最新研究,总结了6项前瞻性队列(共涉及近3万名受试者)的数据后发现,将蛋、加工肉类、未加工红肉或猪肉替换为更健康的蛋白食物(坚果、全谷物、豆类或鱼),与心血管疾病发病率及全因死亡率的降低相关。
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Protein foods from animal sources, incident cardiovascular disease and all-cause mortality: a substitution analysis

动物蛋白食物、心血管疾病发病率及全因死亡率

10.1093/ije/dyaa205

2021-01-07, Article

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Background: Protein-rich foods are major parts of the human diet and are highly heterogeneous in nutrient composition and health effects. Designing healthy diets for disease prevention requires careful consideration of substituting unhealthier protein foods with healthier protein foods.
Methods: This was a pooled analysis of six prospective cohort studies of 29 682 US participants. Data were collected in 1985–2016. Adjusted hazard ratios (HRs) and 30-year absolute risk differences (ARDs) were calculated for the associations between simultaneous substitution of one or more animal protein foods with other animal or plant protein foods at various amounts, and incident cardiovascular disease (CVD) and all-cause mortality.
Results: Substituting eggs, processed meat, unprocessed red meat or poultry with nuts, whole grains, legumes or fish was associated with lower risks of incident CVD and all-cause mortality. According to different substitution amounts (varying from one serving per week to one serving per day) and different numbers of protein foods being simultaneously substituted (varying from one to four), estimates ranged between 1%: HR, 0.99 [95% confidence interval (CI), 0.98–1.00], and 54%: HR, 0.46 (0.35–0.60), lower risks on the relative scale and between 0.3%: ARD, -0.29% (-0.48% to -0.05%), and 14.0%: ARD, -13.96% (-17.29% to -9.96%) lower risks on the absolute scale.
Conclusions: Nuts, whole grains, legumes and fish appeared to be healthier protein sources than eggs, processed meat, unprocessed red meat and poultry for preventing incident CVD and premature death. The magnitude of lower risk for incident CVD and all-cause mortality was driven by amount and number of animal protein foods substituted.

First Authors:
Victor W Zhong

Correspondence Authors:
Victor W Zhong

All Authors:
Victor W Zhong,Norrina B Allen,Philip Greenland,Mercedes R Carnethon,Hongyan Ning,John T Wilkins,Donald M Lloyd-Jones,Linda Van Horn

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