创作:mildbreeze 审核:mildbreeze 06月16日
  • 母鼠肠道菌群诱导的IgG经Fc受体从血清进入母乳,再转移到新生鼠肠道中;
  • 这些母体IgG与致病菌(鼠柠檬酸杆菌)交叉反应,抑制其对新生鼠肠黏膜的黏附和定植;
  • 给无菌小鼠补充诱导IgG的肠菌,或通过让母体接种源自菌群的IgG抗原OMP-A,都能以IgG依赖的方式提高抗致病菌感染免疫力;
  • 在完全缺乏IgG的小鼠模型中,缺乏IgG使新生鼠易被致病菌感染,且其肠道菌群的变化使肠道内的产IL-17A γδT细胞增加,加剧成年后的结肠炎易感性。
Science Immunology发表的一项小鼠研究表明,母体肠道菌群特异性的IgG抗体,能经过母乳转移到后代肠道中,不仅帮助仔鼠抵抗致病菌感染,还参与塑造肠道菌群发育,对后代的免疫功能造成深远影响。这项研究与赵文婧等此前在Nature发表的文章相互印证(查看文章),有兴趣的读者不妨两篇文章一起读读。
Science Immunology [IF:30.63]

Maternal gut microbiome–induced IgG regulates neonatal gut microbiome and immunity



06-10, Article

Abstract & Authors:展开

The gut microbiome elicits antigen-specific immunoglobulin G (IgG) at steady state that cross-reacts to pathogens to confer protection against systemic infection. The role of gut microbiome–specific IgG antibodies in the development of the gut microbiome and immunity against enteric pathogens in early life, however, remains largely undefined. In this study, we show that gut microbiome–induced maternal IgG is transferred to the neonatal intestine through maternal milk via the neonatal Fc receptor and directly inhibits Citrobacter rodentium colonization and attachment to the mucosa. Enhanced neonatal immunity against oral C. rodentium infection was observed after maternal immunization with a gut microbiome–derived IgG antigen, outer membrane protein A, or induction of IgG-inducing gut bacteria. Furthermore, by generating a gene-targeted mouse model with complete IgG deficiency, we demonstrate that IgG knockout neonates are more susceptible to C. rodentium infection and exhibit alterations of the gut microbiome that promote differentiation of interleukin-17A–producing γδ T cells in the intestine, which persist into adulthood and contribute to increased disease severity in a dextran sulfate sodium–induced mouse model of colitis. Together, our studies have defined a critical role for maternal gut microbiome–specific IgG antibodies in promoting immunity against enteric pathogens and shaping the development of the gut microbiome and immune cells in early life.

First Authors:
Katherine Z Sanidad,Mohammed Amir

Correspondence Authors:
Melody Y Zeng

All Authors:
Katherine Z Sanidad,Mohammed Amir,Aparna Ananthanarayanan,Anvita Singaraju,Nicholas B Shiland,Hanna S Hong,Nobuhiko Kamada,Naohiro Inohara,Gabriel Núñez,Melody Y Zeng