Cell子刊:出生第一年,人的肠道菌群会怎么变?(综述)
  • 纳入98对母子,并对其出生后第一年的肠道微生物进行测定;
  • 与经阴道分娩的婴儿相比,剖腹产婴儿的肠道微生物群与母亲肠道微生物群的相似性明显降低;
  • 营养和外源代谢的变化标志着肠道微生物群的成熟;
  • 营养对早期微生物群的组成和功能有重大影响,停止母乳喂养对于婴儿肠道微生物转变为成人样微生物群是必需的,而引入固体食物是非必需的;
  • 微生物群落的组成和生态网络在每个采样阶段都具有不同的特征,与微生物群落的功能匹配相一致。
#Cell Host & Microbe 1月份微生物组专辑# #Cell Press Nucleus微生物组专辑#
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Dynamics and Stabilization of the Human Gut Microbiome during the First Year of Life

人类出生后第一年肠道微生物的动态变化与稳定过程

10.1016/j.chom.2015.04.004

2015-05-13, Article

Abstract & Authors:展开

Abstract:收起
BACKGROUND: The gut microbiota is central to human health, but its establishment in early life has not been quantitatively and functionally examined.
METHODS: Applying metagenomic analysis on fecal samples from a large cohort of Swedish infants and their mothers, we characterized the gut microbiome during the first year of life and assessed the impact of mode of delivery and feeding on its establishment.
RESULTS: In contrast to vaginally delivered infants, the gut microbiota of infants delivered by C-section showed significantly less resemblance to their mothers. Nutrition had a major impact on early microbiota composition and function, with cessation of breast-feeding, rather than introduction of solid food, being required for maturation into an adult-like microbiota. Microbiota composition and ecological network had distinctive features at each sampled stage, in accordance with functional maturation of the microbiome.
CONCLUSIONS: Our findings establish a framework for understanding the interplay between the gut microbiome and the human body in early life.

First Authors:
Fredrik Bäckhed

Correspondence Authors:
Jovanna Dahlgren,Wang Jun,Fredrik Bäckhed

All Authors:
Fredrik Bäckhed,Josefine Roswall,Yangqing Peng,Qiang Feng,Huijue Jia,Petia Kovatcheva-Datchary,Yin Li,Yan Xia,Xie Hailiang,Huanzi Zhong,Muhammad Tanweer Khan,Jianfeng Zhang,Junhua Li,Liang Xiao,Jumana Al-Aama,Dongya Zhang,Ying Shiuan Lee,Dorota Kotowska,Camilla Colding,Valentina Tremaroli,Ye Yin,Stefan Bergman,Xun Xu,Lise Madsen,Karsten Kristiansen,Jovanna Dahlgren,Jun Wang

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宏基因组微信公众号

Cell子刊:新生儿肠道微生物菌群研究

2019-03-29

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WF科技服务微信公众号

科研丨Cell Host&Microbe:出生后首年人类肠道菌群的动态和稳定化

微分基因,2018-09-07

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