类风湿性关节炎患者口腔及肠道菌群受到扰乱且在治疗后部分恢复
创作:大月半 审核:药农 2016年04月30日
  • 纳入类风湿关节炎患者(RA)及健康人的粪便、牙齿及唾液样品,分析三个部位样品菌群组间差异;
  • RA患者口腔及肠道菌群失调,且具有一致性,治疗后菌群可部分恢复;
  • RA患者样本中,嗜血杆菌属消失殆尽且与血清抗体水平呈负相关,唾液乳酸杆菌过表达且与RA活跃程度正相关;
  • 在功能上,RA患者体内的氧化还原环境、铁、硫、锌和精氨酸的转运和代谢发生改变;
  • 检测到与RA相关的人类抗原的分子拟态,提出利用菌群进行预后和诊断的可能方法。
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Nature Medicine [IF:53.44]

The oral and gut microbiomes are perturbed in rheumatoid arthritis and partly normalized after treatment

10.1038/nm.3914

2015-07-27, Article

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We carried out metagenomic shotgun sequencing and a metagenome-wide association study (MGWAS) of fecal, dental and salivary samples from a cohort of individuals with rheumatoid arthritis (RA) and healthy controls. Concordance was observed between the gut and oral microbiomes, suggesting overlap in the abundance and function of species at different body sites. Dysbiosis was detected in the gut and oral microbiomes of RA patients, but it was partially resolved after RA treatment. Alterations in the gut, dental or saliva microbiome distinguished individuals with RA from healthy controls, were correlated with clinical measures and could be used to stratify individuals on the basis of their response to therapy. In particular, Haemophilus spp. were depleted in individuals with RA at all three sites and negatively correlated with levels of serum autoantibodies, whereas Lactobacillus salivarius was over-represented in individuals with RA at all three sites and was present in increased amounts in cases of very active RA. Functionally, the redox environment, transport and metabolism of iron, sulfur, zinc and arginine were altered in the microbiota of individuals with RA. Molecular mimicry of human antigens related to RA was also detectable. Our results establish specific alterations in the gut and oral microbiomes in individuals with RA and suggest potential ways of using microbiome composition for prognosis and diagnosis.

First Authors:
Xuan Zhang,Dongya Zhang,Huijue Jia,Qiang Feng,Donghui Wang,Di Liang

Correspondence Authors:
Xuan Zhang,Yingrui Li,Jun Wang

All Authors:
Xuan Zhang,Dongya Zhang,Huijue Jia,Qiang Feng,Donghui Wang,Di Liang,Xiangni Wu,Junhua Li,Longqing Tang,Yin Li,Zhou Lan,Bing Chen,Yanli Li,Huanzi Zhong,Xie Hailiang,Zhuye Jie,Weineng Chen,Shanmei Tang,xu Xiaoqiang,Xiaokai Wang,Xianghang Cai,Sheng Liu,Yan Xia,Jiyang Li,Xingye Qiao,Jumana Yousuf Al-Aama,Hua Chen,Li Wang,Qing-jun Wu,Fengchun Zhang,Wenjie Zheng,Yongzhe Li,Mingrong Zhang,Guangwen Luo,Wenbin Xue,Liang Xiao,Jun Li,Wanting Chen,Xun Xu,Ye Yin,Huanming Yang,Jian Wang,Karsten Kristiansen,Liang Liu,Ting Li,Qingchun Huang,Yingrui Li,Jun Wang

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