印遇龙等:补铁过多好不好?仔猪模型给答案
创作:鱼儿 审核:好雨 2021年01月21日
  • 在饲粮中浓度梯度补铁不影响仔猪生长,但增加腹泻风险,增加肠道内容物、组织、肝脏及血液中的铁沉积;
  • 高铁饲粮降低血清不饱和铁结合能力、载脂蛋白和IgA水平;
  • 高铁饲粮改变了结肠转录谱,包括IFN-γ信号、G蛋白偶联受体、趋化因子活性等免疫、炎症相关通路;
  • 高铁饲粮改变结肠、盲肠菌群,降低菌群α-多样性,导致梭菌、罗伊氏乳杆菌的相对丰度下降,淀粉乳杆菌相对丰度上升;
  • 膳食铁含量过高或可对宿主和共生菌群产生负面影响。
主编推荐语
好雨
铁是宿主和肠道菌群都必需的重金属元素。通常来讲我们更多遇到的是新生儿缺铁。但补铁过多也未必是益事。近期印遇龙院士、中科院杨焕胜、湖南农大尹杰等在Frontiers in Cell and Developmental Biology 发表文章,利用仔猪模型揭示了膳食铁添加过高对动物生理、代谢、肠道菌群和免疫的影响。机体铁元素储藏或沉积过多或与代谢综合征相关,应予以关注。,
关键字
延伸阅读本研究的原文信息和链接出处,以及相关解读和评论文章。欢迎读者朋友们推荐!

Responses of Intestinal Microbiota and Immunity to Increasing Dietary Levels of Iron Using a Piglet Model

利用仔猪模型研究肠道菌群和免疫对增加饲粮铁水平的反应

10.3389/fcell.2020.603392

2020-12-17, Article

Abstract & Authors:展开

Abstract:收起
Iron is an essential metal for both animals and microbiota. In general, neonates and infants of humans and animals are at the risk of iron insufficiency. However, excess dietary iron usually causes negative impacts on the host and microbiota. This study aimed to investigate overloaded dietary iron supplementation on growth performance, the distribution pattern of iron in the gut lumen and the host, intestinal microbiota, and intestine transcript profile of piglets. Sixty healthy weaning piglets were randomly assigned to six groups: fed on diets supplemented with ferrous sulfate monohydrate at the dose of 50 ppm (Fe50 group), 100 ppm (Fe100 group), 200 ppm (Fe200 group), 500 ppm (Fe500 group), and 800 ppm (Fe800), separately, for 3 weeks. The results indicated that increasing iron had no significant effects on growth performance, but increased diarrheal risk and iron deposition in intestinal digesta, tissues of intestine and liver, and serum. High iron also reduced serum iron-binding capacity, apolipoprotein, and immunoglobin A. The RNA-sequencing analysis revealed that iron changed colonic transcript profile, such as interferon gamma-signal transducer and activator of transcription two-based anti-infection gene network. Increasing iron also shifted colonic and cecal microbiota, such as reducing alpha diversity and the relative abundance of Clostridiales and Lactobacillus reuteri and increasing the relative abundance of Lactobacillus and Lactobacillus amylovorus. Collectively, this study demonstrated that high dietary iron increased diarrheal incidence, changed intestinal immune response-associated gene expression, and shifted gut microbiota. The results would enhance our knowledge of iron effects on the gut and microbiome in piglets and further contribute to understanding these aspects in humans.

First Authors:
Shuai Chen,Xin Wu

Correspondence Authors:
Huansheng Yang,Jie Yin,Yulong Yin

All Authors:
Shuai Chen,Xin Wu,Xia Wang,Yirui Shao,Qiang Tu,Huansheng Yang,Jie Yin,Yulong Yin

评论