秦环龙+秦楠:解析我国长寿老人的肠道菌群和代谢组
创作:圆圈儿 审核:mildbreeze 04月20日
  • 对116个汉族家庭中极长寿老人(94-105 岁)及其子女(50-79 岁)的肠道微生物组和血液代谢组进行比较;
  • 高龄老人存在广泛的宏基因组和代谢组重塑,且其与社会经济因素的相关性存在世代差异;
  • 数量性状位点(QTL)分析表明,遗传与宏基因组和代谢组的关联很大程度上具有世代特异性;
  • 但有131个血浆代谢物与QTL的关联可跨代,集中在6个基因位点,包括FADS1/2与花生四烯酸、PTPA与琥珀酰肉碱以及FLVCR1与胆碱之间的关联。
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mildbreeze
Nature Aging近期发表了来自上海市第十人民医院秦环龙和秦楠与团队的多组学研究,揭示了长寿老人相较于其子女在肠道菌群和血液代谢组方面发生的广泛改变,以及与遗传和社会经济因素等的关联。这些发现提供了与衰老相关的干预新靶标。
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Nature Aging [IF:N/A]

Metagenomic and metabolomic remodeling in nonagenarians and centenarians and its association with genetic and socioeconomic factors

九十岁及百岁老人宏基因组和代谢组重塑及其与遗传和社会经济因素的关系

10.1038/s43587-022-00193-0

04-14, Article

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A better understanding of the biological and environmental variables that contribute to exceptional longevity has the potential to inform the treatment of geriatric diseases and help achieve healthy aging. Here, we compared the gut microbiome and blood metabolome of extremely long-lived individuals (94–105 years old) to that of their children (50–79 years old) in 116 Han Chinese families. We found extensive metagenomic and metabolomic remodeling in advanced age and observed a generational divergence in the correlations with socioeconomic factors. An analysis of quantitative trait loci revealed that genetic associations with metagenomic and metabolomic features were largely generation-specific, but we also found 131 plasma metabolic quantitative trait loci associations that were cross-generational with the genetic variants concentrated in six loci. These included associations between FADS1/2 and arachidonate, PTPA and succinylcarnitine and FLVCR1 and choline. Our characterization of the extensive metagenomic and metabolomic remodeling that occurs in people reaching extreme ages may offer new targets for aging-related interventions.

First Authors:
Qian Xu,Chunyan Wu,Qi Zhu

Correspondence Authors:
Nan Qin,Huanlong Qin

All Authors:
Qian Xu,Chunyan Wu,Qi Zhu,Renyuan Gao,Jianquan Lu,Mireia Valles-Colomer,Jian Zhu,Fang Yin,Linsheng Huang,Lulu Ding,Xiaohui Zhang,Yonghui Zhang,Xiao Xiong,Miaomiao Bi,Xiang Chen,Yefei Zhu,Lin Liu,Yongqiang Liu,Yongshen Chen,Jian Fan,Yan Sun,Jun Wang,Zhan Cao,Chunsun Fan,S Dusko Ehrlich,Nicola Segata,Nan Qin,Huanlong Qin

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