西苑医院:调节肠道菌群无法降低氧化三甲胺水平
创作:aluba 审核:aluba 2021年09月29日
  • 纳入10项随机对照试验(共342名受试者,168名为干预组,174名为对照组)进行荟萃分析,总结菌群调节疗法(益生菌、益生元、合生制剂)对氧化三甲胺及其代谢产物的影响;
  • 入组受试者包括健康人、超重/肥胖患者、慢性肾病患者、心梗患者等;
  • 与对照组相比,菌群调节疗法并未能显著降低循环中的氧化三甲胺水平,对氧化三甲胺的各种代谢产物(胆碱、甜菜醛及L-肉毒碱)的水平也无显著降低作用。
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中国中医科学院西苑医院的曲华团队及史大卓团队在Frontiers in Cardiovascular Medicine上发表的一项荟萃分析结果,总结了10项随机对照试验的数据后发现,益生菌、益生元及合生制剂等菌群调节疗法无法显著降低循环中的氧化三甲胺及其代谢产物的水平。
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Effects of Microbiota-Driven Therapy on Circulating Trimethylamine-N-Oxide Metabolism: A Systematic Review and Meta-Analysis

菌群调节疗法对循环氧化三甲胺

10.3389/fcvm.2021.710567

2021-09-06, Review

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This study was designed to systematically evaluate the effects of microbiota-driven therapy on decreasing TMAO and its related metabolites. PubMed, EMBASE and Cochrane Library databases were searched (up to July 2021). Randomized controlled trials (RCTs), compared microbiota-driven therapy (prebiotics, probiotics, or synbiotics) with placebo on decreasing TMAO and its related metabolites, were eligible. Two researchers extracted the data independently and the disagreement was resolved by a third researcher. The risk of bias of included study was evaluated using Cochrane tool (RoB 2.0). Meta-analysis, meta-regression analysis and publication bias analysis were performed by RevMan 5.3 or Stata 12.0 software. Ten studies (12 arms) involving 342 patients (168 patients in the intervention group and 174 patients in the control group) were included. Compared with the control group, microbiota-driven therapy did not reduce circulating TMAO [SMD = -0.05, 95% CI (-0.36, 0.26), = 0.749], choline [SMD = -0.34, 95% CI (-1.09, 0.41), = 0.373], betaine aldehyde [SMD = -0.704, 95% CI (-1.789, 0.382), = 0.204], and L-carnatine [SMD = -0.06, 95% CI (-0.38, 0.25), = 0.692]. Current evidence does not support that microbiota-driven treatment reduce circulating levels of TMAO, choline, betaine aldehyde, and L-carnitine. However, given the small sample size, this conclusion needs to be proved in the future. PROSPERO:CRD42019119107.

First Authors:
Lina Miao,Jianpeng Du

Correspondence Authors:
Dazhuo Shi,Hua Qu

All Authors:
Lina Miao,Jianpeng Du,Zhuhong Chen,Dazhuo Shi,Hua Qu

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