陈峰+闫志敏:慢性红斑型念珠菌病的口腔菌群变化
  • 纳入12例健康人、12例慢性红斑型念珠菌病患者和2例治愈患者,对唾液微生物群进行宏基因组测序分析;
  • 患者与健康人的菌群组成显著不同,15种细菌在患者中富集,其中丰度最高的是胺胨罗斯氏菌和缓症链球菌;
  • 网络分析表明,白色念珠菌与多种口腔细菌形成紧密联系,特别是与多种链球菌;
  • 功能注释分析鉴定出与疾病相关的微生物标记基因,患者菌群中富集的部分基因参与真核核糖体、假定的谷氨酰胺转运系统和细胞色素bc1复合体呼吸单元等。
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Frontiers in cellular and infection microbiology近期发表了北京大学口腔医学院陈峰、闫志敏与团队的研究,通过宏基因组测序分析,揭示了慢性红斑型念珠菌病患者的口腔菌群的组成和功能变化,提示口腔菌群或可作为该病的预防和治疗靶标。
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Oral Microbiota Composition and Function Changes During Chronic Erythematous Candidiasis

慢性红斑型念珠菌病患者口腔微生物群的组成和功能变化

10.3389/fcimb.2021.691092

2021-08-16, Article

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Oral microbiota is constantly changing with the host state, whereas the oral microbiome of chronic erythematous candidiasis remains poorly understood. The aim of this study was to compare oral microbial signatures and functional profiling between chronic erythematous candidiasis and healthy subjects. Using shotgun metagenomic sequencing, we analyzed the microbiome in 12 chronic erythematous candidiasis, 12 healthy subjects, and 2 chronic erythematous candidiasis cured by antifungal therapy. We found that the salivary microbiota of chronic erythematous candidiasis was significantly different from that of healthy subjects. Among them, and were the most abundant disease-enriched species (Mann-Whitney U-test, < 0.05). In addition, co-occurrence network analysis showed that formed densely connected modules with oral bacterial species and was mainly positive connected to species. Furthermore, we investigated the functional potentials of the microbiome and identified a set of microbial marker genes associated with chronic erythematous candidiasis. Some of these genes enriching in chronic erythematous candidiasis are involved in eukaryotic ribosome, putative glutamine transport system, and cytochrome bc1 complex respiratory unit. Altogether, this study revealed the changes of oral microbial composition, the co-occurrence between and oral bacteria, as well as the changes of microbial marker genes during chronic erythematous candidiasis, which provides evidence of oral microbiome as a target for the treatment and prevention of chronic erythematous candidiasis.

First Authors:
Xin Lyu,Hui Zheng,Xu Wang,Heyu Zhang

Correspondence Authors:
Zhimin Yan,Feng Chen

All Authors:
Xin Lyu,Hui Zheng,Xu Wang,Heyu Zhang,Lu Gao,Zhe Xun,Qian Zhang,Xuesong He,Hong Hua,Zhimin Yan,Feng Chen

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