南方医院陈烨团队:艰难梭菌感染让IBD更难治
  • 南方医院陈烨教授团队成果:
  • 取646位住院成年IBD病人的新鲜粪便样本,检测并分析艰难梭菌感染(CDI);
  • 克罗恩病人(CD)感染率为12.7%,明显低于溃疡性结肠炎(UC)患者的19.3%,毒性株主要为A(+)B(+) 型;
  • CDI患者的住院时间、入院频率和肠道手术率明显高于非感染者;
  • 经2年随访,比起非感染CD病人,感染组病人中,依然处于活跃或更严重阶段的人数较多;
  • 瘘管、抗生素和英夫利昔似乎提高CD病人感染比例,英夫利昔治疗是UC患者风险因素之一。
主编推荐语
蓝灿辉 | 热心肠先生
感染艰难梭菌后的IBD病人,住院时间、入院频率和肠道手术率明显高于非感染者,2年随访还发现病情比起非感染病人,更不乐观。南方医院陈烨教授和团队的最新成果,将研究着眼点放在了解决临床问题上,给IBD病人的治疗提供了新的关注点,这篇文章值得看一看。
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Scientific Reports [IF:4.379]

Clostridium Difficile Infection Worsen Outcome of Hospitalized Patients with Inflammatory Bowel Disease

艰难梭菌的感染使得住院IBD病人的病情恶化

10.1038/srep29791

2016-07-15, Article

Abstract & Authors:展开

Abstract:收起
The prevalence of Clostridium difficile infection (CDI) in patients suffering from inflammatory bowel disease (IBD) has increased rapidly over the past several decades in North America and Europe. However, the exact global epidemiology remains unclear because of insufficient data from developing countries. A total of 646 hospitalized adult IBD patients were enrolled; and their fresh stool specimens were obtained and used for Clostridium difficile detection. The incidence of CDI in Crohn's disease (CD) patients (12.7%) was significantly lower than that in Ulcerative disease (UC) patients (19.3%). Among the toxin types, A(+)B(+) strain was the most common. Length of stay, hospitalization frequency and bowel surgery rate were significantly higher in the CDI than in the non-CDI group in CD or UC patients. More patients in CDI-CD group were still in active and even clinical moderate or severe CD stage than non-CDI-CD group after 2 years of following-up. Fistula, antibiotics and infliximab usage likely increased the CDI rate in CD patients, Infliximab treatment was considered a risk factor in UC patients. CDI is an exacerbating public health issue that may influence IBD course, increase expenditures, and delay the remission of IBD patients. IBD patients with CDI require urgent attention.

First Authors:
Ting Zhang,Qianyun Lin

Correspondence Authors:
Ye Chen

All Authors:
Ting Zhang,Qianyun Lin,Jia-Xi Fei,Yan Zhang,Min-Yi Lin,Shuang-Hong Jiang,Pu Wang,Ye Chen

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