在过去的一年多时间里,全球肠道领域研究继续高歌猛进,取得了颇多令人瞩目的进展。
今年5月29日“世界肠道健康日”,我们基于《热心肠日报》中收录的2021年以来发表的肠道领域论文,进行了多维度评选,形成了《热心肠日报》2022年度榜单。
2022年度榜单参评的文章共有3955篇,发表在441个不同的期刊上,累计影响因子达到了70979.04,平均影响因子17.95。其中来自Cell、Nature、Science的文章168篇,来自NEJM、Lancet、JAMA的文章68篇。
本榜单仅代表热心肠研究院基于自身数据所做的优选,可能存在主观因素干扰等不足,仅供参考。欢迎在文末留言提出批评、建议和意见。
本篇发布“全球肠道菌群研究五大机构”。
提示:下述文章点击中文标题可直达热心肠日报,点击英文标题可访问论文官网。
哈佛大学
代表性科学家(部分)
Emily Balskus
A Sloan Devlin
Jun Huh
Curtis Huttenhower
Dennis Kasper
Aleksandar Kostic
Seth Rakoff-Nahoum
Ramnik Xavier
2021年以来代表性论文(部分)
Nature. 2022 Mar;603(7903):907-912. doi: 10.1038/s41586-022-04480-z
Human gut bacteria produce ΤΗ17-modulating bile acid metabolites
Nature. 2021 Jun;594(7862):234-239. doi: 10.1038/s41586-021-03532-0
Reconstruction of ancient microbial genomes from the human gut
Nature. 2021 Dec;600(7888):302-307. doi: 10.1038/s41586-021-04083-0
Host immunomodulatory lipids created by symbionts from dietary amino acids
Nature. 2022 Mar;603(7900):315-320. doi: 10.1038/s41586-022-04444-3
The bacterial toxin colibactin triggers prophage induction
Nature. 2021 Feb;590(7846):473-479. doi: 10.1038/s41586-020-03116-4
Gut-licensed IFNγ+ NK cells drive LAMP1+TRAIL+ anti-inflammatory astrocytes
Nature. 2021 Nov;599(7885):458-464. doi: 10.1038/s41586-021-03832-5
Novel bile acid biosynthetic pathways are enriched in the microbiome of centenarians
Nature. 2021 Mar;591(7851):633-638. doi: 10.1038/s41586-021-03241-8
Multi-kingdom ecological drivers of microbiota assembly in preterm infants
Cell. 2022 Feb 3;185(3):513-529.e21. doi: 10.1016/j.cell.2022.01.002
Strain-level fitness in the gut microbiome is an emergent property of glycans and a single metabolite
Nat Med. 2021 Feb;27(2):333-343. doi: 10.1038/s41591-020-01223-3
The gut microbiome modulates the protective association between a Mediterranean diet and cardiometabolic disease risk
Nat Med. 2021 Jul;27(7):1212-1222. doi: 10.1038/s41591-021-01390-x
Self-tunable engineered yeast probiotics for the treatment of inflammatory bowel disease
Immunity. 2022 Jan 11;55(1):145-158.e7. doi: 10.1016/j.immuni.2021.11.005
Maternal gut bacteria drive intestinal inflammation in offspring with neurodevelopmental disorders by altering the chromatin landscape of CD4+ T cells
Nat Biomed Eng. 2021 Nov;5(11):1377-1388. doi: 10.1038/s41551-021-00749-2
Generation of systemic antitumour immunity via the in situ modulation of the gut microbiome by an orally administered inulin gel
美国国立卫生研究院
代表性科学家(部分)
Yasmine Belkaid
Daniel Douek
Romina Goldszmid
Chuan Wu(吴船)
Giorgio Trinchieri
2021年以来代表性论文(部分)
Science. 2021 Feb 5;371(6529):595-602. doi: 10.1126/science.abf3363
Fecal microbiota transplant overcomes resistance to anti–PD-1 therapy in melanoma patients
Science. 2021 Dec 24;374(6575):1632-1640. doi: 10.1126/science.aaz7015
Dietary fiber and probiotics influence the gut microbiome and melanoma immunotherapy response
Cell. 2021 Feb 4;184(3):615-627.e17. doi: 10.1016/j.cell.2020.12.011
Infection trains the host for microbiota-enhanced resistance to pathogens
Cell. 2022 Mar 31;185(7):1172-1188.e28. doi: 10.1016/j.cell.2022.02.013
Mucus sialylation determines intestinal host-commensal homeostasis
Cell. 2021 Oct 14;184(21):5338-5356.e21. doi: 10.1016/j.cell.2021.09.019
Microbiota triggers STING-type I IFN-dependent monocyte reprogramming of the tumor microenvironment
Cell. 2021 Jul 22;184(15):3899-3914.e16. doi: 10.1016/j.cell.2021.05.023
Translocated microbiome composition determines immunological outcome in treated HIV infection
Nat Med. 2022 Mar;28(3):545-556. doi: 10.1038/s41591-022-01698-2
Intestinal microbiota signatures of clinical response and immune-related adverse events in melanoma patients treated with anti-PD-1
康奈尔大学
代表性科学家(部分)
Gretchen Diehl
ChunJun Guo(郭春君)
Iliyan Iliev
Christopher Mason
2021年以来代表性论文(部分)
Nature. 2022 Mar;603(7902):672-678. doi: 10.1038/s41586-022-04502-w
Immune regulation by fungal strain diversity in inflammatory bowel disease
Nature. 2021 Jun;594(7863):413-417. doi: 10.1038/s41586-021-03531-1
Thymic development of gut-microbiota-specific T cells
Cell. 2021 Feb 18;184(4):1017-1031.e14. doi: 10.1016/j.cell.2021.01.016
Human gut mycobiota tune immunity via CARD9-dependent induction of anti-fungal IgG antibodies
Cell. 2022 Mar 3;185(5):831-846.e14. doi: 10.1016/j.cell.2022.01.017
Mucosal fungi promote gut barrier function and social behavior via Type 17 immunity
Cell. 2022 Feb 3;185(3):547-562.e22. doi: 10.1016/j.cell.2021.12.035
Genetic manipulation of gut microbes enables single-gene interrogation in a complex microbiome
Gastroenterology. 2022 Jan;162(1):166-178. doi: 10.1053/j.gastro.2021.09.061
Transferable IgA-coated Odoribacter splanchnicus in Responders to Fecal Microbiota Transplantation for Ulcerative Colitis Limits Colonic Inflammation
魏茨曼科学研究所
代表性科学家(部分)
Eran Elinav
Eran Segal
Rotem Sorek
Ravid Straussman
2021年以来代表性论文(部分)
Nature. 2021 Dec;600(7890):713-719. doi: 10.1038/s41586-021-04194-8
Gut microbiota modulates weight gain in mice after discontinued smoke exposure
Nature. 2021 Apr;592(7852):138-143. doi: 10.1038/s41586-021-03368-8
Identification of bacteria-derived HLA-bound peptides in melanoma
Science. 2021 Apr 16;372(6539):eabb5352. doi: 10.1126/science.abb5352
Diversity and functional landscapes in the microbiota of animals in the wild
Science. 2021 Jan 22;371(6527):400-405. doi: 10.1126/science.aba8026
Host succinate is an activation signal for Salmonella virulence during intracellular infection
Nat Med. 2021 Aug;27(8):1442-1450. doi: 10.1038/s41591-021-01409-3
Population-wide diversity and stability of serum antibody epitope repertoires against human microbiota
Nat Med. 2022 Feb;28(2):295-302. doi: 10.1038/s41591-022-01686-6
Metabolomic and microbiome profiling reveals personalized risk factors for coronary artery disease
Cancer Cell. 2021 Oct 11;39(10):1317-1341. doi: 10.1016/j.ccell.2021.08.006
Microbiome and cancer
德州大学系统
代表性科学家(部分)
Carrie Daniel
Lora Hooper
Jennifer Wargo
2021年以来代表性论文(部分)
Science. 2021 Dec 24;374(6575):1632-1640. doi: 10.1126/science.aaz7015
Dietary fiber and probiotics influence the gut microbiome and melanoma immunotherapy response
Science. 2021 Nov 5;374(6568):eabe6723. doi: 10.1126/science.abe6723
Small proline-rich protein 2A is a gut bactericidal protein deployed during helminth infection
Cell. 2021 Aug 5;184(16):4154-4167.e12. doi: 10.1016/j.cell.2021.07.001
The microbiota coordinates diurnal rhythms in innate immunity with the circadian clock
Nat Med. 2021 Aug;27(8):1432-1441. doi: 10.1038/s41591-021-01406-6
Gut microbiota signatures are associated with toxicity to combined CTLA-4 and PD-1 blockade
Nat Med. 2022 Apr;28(4):690-703. doi: 10.1038/s41591-022-01779-2