《热心肠日报》2021-2022榜单 | 全球肠道菌群研究五大机构
热心肠小伙伴们 2022-06-02
本篇发布“全球肠道菌群研究五大机构”。
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在过去的一年多时间里,全球肠道领域研究继续高歌猛进,取得了颇多令人瞩目的进展。

 

今年5月29日“世界肠道健康日”,我们基于《热心肠日报》中收录的2021年以来发表的肠道领域论文,进行了多维度评选,形成了《热心肠日报》2022年度榜单。

 

2022年度榜单参评的文章共有3955篇,发表在441个不同的期刊上,累计影响因子达到了70979.04,平均影响因子17.95。其中来自Cell、Nature、Science的文章168篇,来自NEJM、Lancet、JAMA的文章68篇。

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本榜单仅代表热心肠研究院基于自身数据所做的优选,可能存在主观因素干扰等不足,仅供参考。欢迎在文末留言提出批评、建议和意见。

 

本篇发布“全球肠道菌群研究五大机构”

 

提示:下述文章点击中文标题可直达热心肠日报,点击英文标题可访问论文官网。

 

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哈佛大学

 

代表性科学家(部分)

Emily Balskus

A Sloan Devlin

Jun Huh

Curtis Huttenhower

Dennis Kasper

Aleksandar Kostic

Seth Rakoff-Nahoum

Ramnik Xavier

 

2021年以来代表性论文(部分)

Nature:人肠道细菌的胆汁酸代谢物可调节TH17,或可影响IBD

Nature. 2022 Mar;603(7903):907-912. doi: 10.1038/s41586-022-04480-z

Human gut bacteria produce ΤΗ17-modulating bile acid metabolites

 

Nature揭秘:距今千年的古人肠道里有啥微生物?

Nature. 2021 Jun;594(7862):234-239. doi: 10.1038/s41586-021-03532-0

Reconstruction of ancient microbial genomes from the human gut

 

Nature:脆弱拟杆菌利用膳食氨基酸产生调控宿主免疫的代谢物

Nature. 2021 Dec;600(7888):302-307. doi: 10.1038/s41586-021-04083-0

Host immunomodulatory lipids created by symbionts from dietary amino acids

 

Nature:促肠癌的细菌毒素可引爆其他肠菌内的“不定时炸弹”

Nature. 2022 Mar;603(7900):315-320. doi: 10.1038/s41586-022-04444-3

The bacterial toxin colibactin triggers prophage induction

 

Nature:肠道菌群“训练”的免疫细胞,帮助大脑抗炎症

Nature. 2021 Feb;590(7846):473-479. doi: 10.1038/s41586-020-03116-4

Gut-licensed IFNγ+ NK cells drive LAMP1+TRAIL+ anti-inflammatory astrocytes

 

Nature聚焦百岁老人肠道菌群:一组特殊的胆汁酸或助长寿

Nature. 2021 Nov;599(7885):458-464. doi: 10.1038/s41586-021-03832-5

Novel bile acid biosynthetic pathways are enriched in the microbiome of centenarians

 

Nature:微生物之间的相互作用如何驱动早产儿肠道菌群的演变?

Nature. 2021 Mar;591(7851):633-638. doi: 10.1038/s41586-021-03241-8

Multi-kingdom ecological drivers of microbiota assembly in preterm infants

 

Cell:饮食和菌群代谢物如何影响肠菌?从糖和丁酸的互作窥视冰山一角

Cell. 2022 Feb 3;185(3):513-529.e21. doi: 10.1016/j.cell.2022.01.002

Strain-level fitness in the gut microbiome is an emergent property of glycans and a single metabolite

 

Nature子刊:肠道细菌影响地中海饮食的“食疗”效果

Nat Med. 2021 Feb;27(2):333-343. doi: 10.1038/s41591-020-01223-3

The gut microbiome modulates the protective association between a Mediterranean diet and cardiometabolic disease risk

 

Nature子刊:巧妙改造酵母益生菌,抑制肠道炎症

Nat Med. 2021 Jul;27(7):1212-1222. doi: 10.1038/s41591-021-01390-x

Self-tunable engineered yeast probiotics for the treatment of inflammatory bowel disease

 

Cell子刊:自闭症为何易伴随肠道炎症?

Immunity. 2022 Jan 11;55(1):145-158.e7. doi: 10.1016/j.immuni.2021.11.005

Maternal gut bacteria drive intestinal inflammation in offspring with neurodevelopmental disorders by altering the chromatin landscape of CD4+ T cells

 

Nature子刊:菊粉凝胶或能强化抗PD-1免疫治疗

Nat Biomed Eng. 2021 Nov;5(11):1377-1388. doi: 10.1038/s41551-021-00749-2

Generation of systemic antitumour immunity via the in situ modulation of the gut microbiome by an orally administered inulin gel

 

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美国国立卫生研究院

 

代表性科学家(部分)

Yasmine Belkaid

Daniel Douek

Romina Goldszmid

Chuan Wu(吴船)

Giorgio Trinchieri

 

2021年以来代表性论文(部分)

Science:粪菌移植可帮助黑色素瘤患者应答抗PD-1治疗

Science. 2021 Feb 5;371(6529):595-602. doi: 10.1126/science.abf3363

Fecal microbiota transplant overcomes resistance to anti–PD-1 therapy in melanoma patients

 

Science:高纤维饮食或有益免疫治疗,益生菌存疑

Science. 2021 Dec 24;374(6575):1632-1640. doi: 10.1126/science.aaz7015

Dietary fiber and probiotics influence the gut microbiome and melanoma immunotherapy response

 

Cell:感染“训练”宿主,“升级”菌群对病原体的抵抗力

Cell. 2021 Feb 4;184(3):615-627.e17. doi: 10.1016/j.cell.2020.12.011

Infection trains the host for microbiota-enhanced resistance to pathogens

 

Cell:黏蛋白唾液酸化增强肠道黏液屏障,促进与菌群和谐共生

Cell. 2022 Mar 31;185(7):1172-1188.e28. doi: 10.1016/j.cell.2022.02.013

Mucus sialylation determines intestinal host-commensal homeostasis

 

Cell:菌群调控抗肿瘤免疫的新机制

Cell. 2021 Oct 14;184(21):5338-5356.e21. doi: 10.1016/j.cell.2021.09.019

Microbiota triggers STING-type I IFN-dependent monocyte reprogramming of the tumor microenvironment

 

Cell:血液微生物组或影响HIV患者的免疫重建

Cell. 2021 Jul 22;184(15):3899-3914.e16. doi: 10.1016/j.cell.2021.05.023

Translocated microbiome composition determines immunological outcome in treated HIV infection

 

Nature子刊:肠道菌群可影响黑色素瘤患者对PD-1单抗治疗的应答

Nat Med. 2022 Mar;28(3):545-556. doi: 10.1038/s41591-022-01698-2

Intestinal microbiota signatures of clinical response and immune-related adverse events in melanoma patients treated with anti-PD-1

 

康奈尔大学

 

代表性科学家(部分)

Gretchen Diehl

ChunJun Guo(郭春君)

Iliyan Iliev

Christopher Mason

 

2021年以来代表性论文(部分)

Nature:真菌对肠道炎症的菌株特异性影响

Nature. 2022 Mar;603(7902):672-678. doi: 10.1038/s41586-022-04502-w

Immune regulation by fungal strain diversity in inflammatory bowel disease


Nature:胸腺中的菌群特异性T细胞的产生及作用

Nature. 2021 Jun;594(7863):413-417. doi: 10.1038/s41586-021-03531-1

Thymic development of gut-microbiota-specific T cells

 

Cell:肠道真菌如何塑造抗真菌免疫?

Cell. 2021 Feb 18;184(4):1017-1031.e14. doi: 10.1016/j.cell.2021.01.016

Human gut mycobiota tune immunity via CARD9-dependent induction of anti-fungal IgG antibodies

 

Cell:黏膜真菌保护肠道屏障,并促进社交行为

Cell. 2022 Mar 3;185(5):831-846.e14. doi: 10.1016/j.cell.2022.01.017

Mucosal fungi promote gut barrier function and social behavior via Type 17 immunity

 

郭春君团队Cell突破:在复杂菌群中揭示单个肠菌基因功能,新方法来了

Cell. 2022 Feb 3;185(3):547-562.e22. doi: 10.1016/j.cell.2021.12.035

Genetic manipulation of gut microbes enables single-gene interrogation in a complex microbiome

 

找出FMT改善结肠炎的关键肠菌

Gastroenterology. 2022 Jan;162(1):166-178. doi: 10.1053/j.gastro.2021.09.061

Transferable IgA-coated Odoribacter splanchnicus in Responders to Fecal Microbiota Transplantation for Ulcerative Colitis Limits Colonic Inflammation

 

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魏茨曼科学研究所

 

代表性科学家(部分)

Eran Elinav

Eran Segal

Rotem Sorek

Ravid Straussman

 

2021年以来代表性论文(部分)

Nature:戒烟后为何易长胖?肠道菌群在偷偷捣鬼

Nature. 2021 Dec;600(7890):713-719. doi: 10.1038/s41586-021-04194-8

Gut microbiota modulates weight gain in mice after discontinued smoke exposure

 

Nature:肿瘤细菌多肽或为癌症免疫治疗提供新靶点

Nature. 2021 Apr;592(7852):138-143. doi: 10.1038/s41586-021-03368-8

Identification of bacteria-derived HLA-bound peptides in melanoma

 

Science:野生动物肠道菌群——有待深入挖掘的宝库

Science. 2021 Apr 16;372(6539):eabb5352. doi: 10.1126/science.abb5352

Diversity and functional landscapes in the microbiota of animals in the wild

 

Science: 巨噬细胞代谢编程vs.沙门氏菌毒力编程

Science. 2021 Jan 22;371(6527):400-405. doi: 10.1126/science.aba8026

Host succinate is an activation signal for Salmonella virulence during intracellular infection

 

Nature子刊:基于菌群的人体免疫学“指纹”

Nat Med. 2021 Aug;27(8):1442-1450. doi: 10.1038/s41591-021-01409-3

Population-wide diversity and stability of serum antibody epitope repertoires against human microbiota

 

Nature子刊:代谢组+微生物组,揭示心血管疾病的个体化风险因素

Nat Med. 2022 Feb;28(2):295-302. doi: 10.1038/s41591-022-01686-6

Metabolomic and microbiome profiling reveals personalized risk factors for coronary artery disease

 

Cell子刊:微生物组与癌症(一图+一文读懂)

Cancer Cell. 2021 Oct 11;39(10):1317-1341. doi: 10.1016/j.ccell.2021.08.006

Microbiome and cancer

 

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德州大学系统

 

代表性科学家(部分)

Carrie Daniel

Lora Hooper

Jennifer Wargo

 

2021年以来代表性论文(部分)

Science:高纤维饮食或有益免疫治疗,益生菌存疑

Science. 2021 Dec 24;374(6575):1632-1640. doi: 10.1126/science.aaz7015

Dietary fiber and probiotics influence the gut microbiome and melanoma immunotherapy response

 

胡泽汗等Science突破:一种新型肠道抗菌蛋白,在寄生虫感染时保护肠屏障

Science. 2021 Nov 5;374(6568):eabe6723. doi: 10.1126/science.abe6723

Small proline-rich protein 2A is a gut bactericidal protein deployed during helminth infection

 

Cell:生物钟通过肠道菌群调控先天性免疫的昼夜节律

Cell. 2021 Aug 5;184(16):4154-4167.e12. doi: 10.1016/j.cell.2021.07.001

The microbiota coordinates diurnal rhythms in innate immunity with the circadian clock

 

Nature子刊:肠道菌群或影响癌症免疫治疗毒性

Nat Med. 2021 Aug;27(8):1432-1441. doi: 10.1038/s41591-021-01406-6

Gut microbiota signatures are associated with toxicity to combined CTLA-4 and PD-1 blockade

 

Nature子刊:如何利用菌群更好地预防和治疗癌症(综述)

Nat Med. 2022 Apr;28(4):690-703. doi: 10.1038/s41591-022-01779-2

Targeting the gut and tumor microbiota in cancer

 

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