小鼠:秦岭中华蜂蜜具有减轻酒精性肝损伤潜力
创作:女巫 审核:JIAN 剑 2017年10月30日
  • 秦岭山脉的中华蜂蜜富含多酚和抗坏血酸,具有较强的抗氧化活性、铁还原抗氧化能力和亚铁离子鳌合活性。
  • 小鼠每日两次服用5、10或20g/kg中华蜂蜜12周,可显著抑制血清脂蛋白氧化水平,增强血清抗氧化能力。
  • 中华蜂蜜抑制酒精引起的ALT和AST升高,降低肝脏丙二醛的生成,促进超氧化物歧化酶和谷胱甘肽过氧化物酶活性,显著抑制血清和肝脏中的TGF-β1水平。
  • 通过改善氧化应激引起的损伤,食用中华蜂蜜具有减轻急性酒精性肝损伤的潜力。
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Antioxidant and hepatoprotective effects of A. cerana honey against acute alcohol-induced liver damage in mice

中华蜂蜜对小鼠急性酒精性肝损伤的抗氧化和保肝作用

10.1016/j.foodres.2017.08.014

2017-11-01, Article

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A. cerana honey, gathered from Apis cerana Fabricius (A. cerana), has not been fully studied. Samples of honey originating from six geographical regions (mainly in the Qinling Mountains of China) were investigated to determine their antioxidant and hepatoprotective effects against acute alcohol-induced liver damage. The results showed that A. cerana honeys from the Qinling Mountains had high total phenolic contents (345.1-502.1mgGAkg(-1)), ascorbic acid contents (153.8-368.4mgkg(-1)), and strong antioxidant activities in DPPH radical scavenging activity assays (87.5-136.2IC50mgmL(-1)), ferric reducing antioxidant powers (191.8-317.4mgTroloxkg(-1)), and ferrous ion-chelating activities (27.5-35.5mgNa2EDTAkg(-1)). Pretreatment with A. cerana honey (Qinling Mountains) at 5, 10, or 20gkg(-1) twice daily for 12weeks significantly inhibited serum lipoprotein oxidation and increased serum radical absorbance capacity (ORAC) (P<0.05). Moreover, A. cerana honey inhibited acute alcohol-induced increases in alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in serum (P<0.05), reduced the production of hepatic malondialdehyde (MDA) (P<0.05), and promoted superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activities (P<0.05). More importantly, it also remarkably inhibited the level of TGF-β1 in the serum and liver (P<0.05). The results of this study indicate that administration of A. cerana honey prevents acute alcohol-induced liver damage likely because of its antioxidant properties and ability to prevent oxidative stress.

First Authors:
Haoan Zhao

Correspondence Authors:
Liming Wu,Wei Cao

All Authors:
Haoan Zhao,Ni Cheng,Liangliang He,Guoxia Peng,Xiaofeng Xue,Liming Wu,Wei Cao

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