菊粉对胆固醇代谢无显著影响

创作:MAY DAY 审核:小肠君 11月09日
在已有的人体和临床前试验中,菊糖对胆固醇平衡的影响并不一致;
在饮食中添加10%的短链或长链菊粉两周后,野生型小鼠粪便中短链脂肪酸(SCFA)水平比对照组提高了约2.5倍(P < 0.01),血液β-鼠胆酸水平升高1.7倍(P < 0.05);
对小鼠血液、肝脏脂肪以及胆固醇的肠道吸收、粪便排泄或肠内分泌均无显著影响;
短链和长链菊粉能够促进SCFA的产生,但不影响小鼠的胆固醇代谢。
延伸阅读
Scientific Reports [IF:4.122]

Effect of the prebiotic fiber inulin on cholesterol metabolism in wildtype mice

益生元纤维菊粉对野生型小鼠胆固醇代谢的影响

09-05, Article, 10.1038/s41598-018-31698-7more

Abstract:
Dietary non-digestible carbohydrates are perceived to improve health via gut microbiota-dependent generation of products such as short-chain fatty acids (SCFA). In addition, SCFA are also precursors for lipid and cholesterol synthesis potentially resulting in unwanted effects on lipid metabolism. Inulin is a widely used model prebiotic dietary fiber. Inconsistent reports on the effects of inulin on cholesterol homeostasis have emerged in humans and preclinical models. To clarify this issue, the present study aimed to provide an in-depth characterization of the effects of short-chain (sc)- and long-chain (lc)- inulin on cholesterol synthesis, absorption and elimination in mice. Feeding wildtype C57BL/6J mice diets supplemented with 10% (w/w) of either sc- or lc-inulin for two weeks resulted in approximately 2.5-fold higher fecal SCFA levels (P < 0.01) compared with controls, but had no significant effects on plasma and liver lipids. Subtle shifts in fecal and plasma bile acid species were detected with beta-muricholic acid increasing significantly in plasma of the inulin fed groups (1.7-fold, P < 0.05). However, neither sc-inulin nor lc-inulin affected intestinal cholesterol absorption, mass fecal cholesterol excretion or trans-intestinal cholesterol excretion (TICE). Combined, our data demonstrate that sc- and lc-inulin have no adverse effects on cholesterol metabolism in mice despite increased generation of SCFA.

First Authors:
Rima H Mistry

Correspondence Authors:
Uwe J F Tietge

All Authors:
Rima H Mistry,Fangjie Gu,Henk A Schols,Henkjan J Verkade,Uwe J F Tietge