柑橘多酚通过抗氧化有助于肝脏健康

创作:xinyan 审核:JIAN 剑 07月11日
高血糖、胰岛素抗性、肥胖和心血管功能障碍是影响肝脏疾病及并发症发展的关键因素。
肝功能异常的传统疗法由于药物不良反应和并发症较少而逐渐被认识。
柑橘类是常见的季节性水果, 我们回顾了柑橘多酚与肝功能障碍的分子生物学理论。
柑橘中的多酚对炎症细胞因子、促纤维化因子及阻碍自由基生成有积极作用;可诱导防御基因如Nrf2、AMPK、超氧化物歧化酶、过氧化氢酶、血红素加氧酶和SIRT1,为线粒体生物合成提供重要的功能蛋白。
延伸阅读

Beneficial Role of Citrus Fruit Polyphenols Against Hepatic Dysfunctions: A Review

柑橘类水果茶多酚对肝障碍的有益作用回顾

03-04, Review, 10.1080/19390211.2017.1330301more

Abstract:
Alcoholic liver diseases and virus-induced hepatic dysfunctions are prevalent in western countries. Evidence also suggests that hyperglycemia and insulin resistance are key players in the development of hepatic diseases and their complications. Since the comorbid diseases like obesity, diabetes and vascular dysfunctions primarily affect liver, the modern therapies against other hepatic dysfunctions are becoming a major challenge to treat. In addition to these, polypharmacy and adverse drug reactions (ADRs) are further aggravating the phenomenon. Production of interleukins (IL) 1β, tumor necrosis factors (TNF) α, nuclear factor (NF) κB, activator protein (AP) 1, macrophage inflammatory protein (MIP), toll-like receptor (TLR) 4, and several other harmful cytokines are often evaluated for clinical significance in hepatic complications as recommended by much evidence. On the other hand, transforming growth factors (TGF) β, matrix metalloproteinases, and extracellular matrix- (ECM-) mediated hepatic fibrosis have been identified as major targets. However, modern medicines rely not only on synthetic compounds but also on herbal sources. Traditional therapies are gradually being acknowledged due to having fewer ADRs and other complications. Citrus fruits are generally seen all over the world and offer a great value as seasonal fruit. Several important biologically active components such as polyphenols, flavonols, carbohydrates, amino acids, and oils have been isolated from this family. Evidence suggests that polyphenol-based therapies have already proved their high potency against the production of inflammatory cytokines and profibrogenic factors. Along with the prevention of oxidative stress, these molecules hinder the generation of free radicals. Furthermore, polyphenols induce several defensive genes such as Nrf2, AMPK, superoxide dismutase, catalase, heme oxygenase (HO), Sirt1, and other important functional proteins to serve mitochondrial biogenesis. Therefore, this review will try to establish some molecular theories between citrus polyphenols and liver dysfunctions.

First Authors:
Mohabbulla Mohib

Correspondence Authors:
Mohabbulla Mohib

All Authors:
Mohabbulla Mohib,Kazi Afnan,Tasfiq Zaman Paran,Salma Khan,Juthika Sarker,Nahid Hasan,Istiaque Hasan,Abu Taher Sagor