地中海枣:减少杀虫剂引起的生理损伤

创作:女巫 审核:yingjian 2018年01月12日
Zizyphus lotus jujube是一种生长在地中海地区的枣;考察其是否可以减少杀虫剂氯氰菊酯(CYP)引起的损伤。
将小鼠分成四组:对照组、口服枣组、CYP组和CYP+口服枣组。
在心脏、肝脏和肾脏中,CYP降低过氧化氢酶活性、抑制乙酰胆碱酯酶活性和升高过氧化氢和丙二醛水平;而同时用CYP和枣可显著恢复以上变化,减少CYP的有害作用。
枣之所以能保护小鼠免受CYP诱导产生的生理损伤,可能是由于其抗氧化性和对活性自由基的清除能力。
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Biomarkers [IF:1.73]

Protective effect of Zizyphus lotus jujube fruits against cypermethrin-induced oxidative stress and neurotoxicity in mice

枣果实对小鼠中氯氰菊酯诱导的氧化应激和神经毒性的保护作用

10.1080/1354750X.2017.1390609

2017-10-20, Article

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CONTEXT: Cypermethrin (CYP) is a synthetic pyrethroid insecticide used worldwide in agriculture, home pest control. The toxicity of CYP is well studied in many organisms.
OBJECTIVE: The aim of present study was to investigate the protective effect of Zizyphus lotus (Zizyp) fruit against neurotoxicity and oxidative stress induced by CYP in mice.
MATERIALS AND METHODS: Mice were divided into four groups of six each: groups I and II were used as control and CYP control (20 mg/kg body weight). While, groups III was orally treated with Zizyphus lotus fruit (5 g/kg body weight) plus CYP (20 mg/kg body weight) for 18 days. Furthermore, HPLC-ESI-MS-MS (Q-Tof) and GC-MS were used to identify the compounds fraction.
RESULTS: Antioxidant enzyme catalase (CAT), neurotoxicity enzyme acetylcholinesterase (AChE) activities and hydrogen peroxide (H2O2), malondialdehyde (MDA) levels were determined in the liver, kidney and heart. CYP caused decreased CAT activity, inhibition of AChE activity and increased the levels of H2O2 and MDA in heart, liver and kidney.
CONCLUSION: Our results indicate that Zizyp fruit is markedly effective in protecting mice against CYP-induced biochemical changes. This protection may be due to its antioxidant property and scavenging ability against active free radicals.

First Authors:
Khazri Abdelhafidh

Correspondence Authors:
Khazri Abdelhafidh

All Authors:
Khazri Abdelhafidh,Lazher Mhadhbi,Ali Mezni,Sellami Badreddine,Hamouda Beyrem,Ezzeddine Mahmoudi