Cell子刊:婴儿下呼吸道菌群与免疫环境的形成

创作:女巫 审核:mildbreeze 12月06日
分析生命第一年内下呼吸道的细菌定殖和免疫系统成熟情况;
下呼吸道菌群在出生后的前2个月内形成,多样性在达到稳定之前逐渐增加;
最初几周的菌群可聚类为三个类型,分别以葡萄球菌、脲原体和多样化菌群为特征,有不同的毒力潜力,包括对粘膜免疫中免疫球蛋白A(IgA)的蛋白水解作用;
分娩方式决定早产儿而非足月儿的菌群组成;
胎龄是免疫成熟的关键决定因素,气道细胞逐渐增加过敏性细胞因子白介素-33和IgA相关基因的表达。
延伸阅读
Cell Host and Microbe [IF:17.872]

Early-Life Formation of the Microbial and Immunological Environment of the Human Airways

生命早期人类呼吸道菌群和免疫环境的形成

11-29, Article, 10.1016/j.chom.2018.10.019more

Abstract:
Crosstalk between immune cells and the microbiota in mucosal tissues can set an individual on a trajectory toward health or disease. Little is known about these early-life events in the human respiratory tract. We examined bacterial colonization and immune system maturation in the lower airways over the first year of life. The lower respiratory tract microbiota forms within the first 2 postnatal months. Within the first weeks, three microbial profiles are evident, broadly distinguished as dysbiotic or diverse, and representing different microbial virulence potentials, including proteolysis of immunoglobulin A (IgA) that is critical for mucosal defense. Delivery mode determines microbiota constituents in preterm, but not term, births. Gestational age is a key determinant of immune maturation, with airway cells progressively increasing expression of proallergic cytokine interleukin-33 and genes linked with IgA. These data reveal microbial and immunological development in human airways, and may inform early-life interventions to prevent respiratory diseases.

First Authors:
Ce´ line Pattaroni

Correspondence Authors:
Benjamin J Marsland

All Authors:
Ce´ line Pattaroni,Martin L Watzenboeck,Sabrina Schneidegger,Silas Kieser,Nicholas C Wong,Eric Bernasconi,Julie Pernot,Louis Mercier,Sylvia Knapp,Laurent P Nicod,Colin P Marsland,Matthias Roth-Kleiner,Benjamin J Marsland