Lancet子刊:用营养干预来预防老年认知障碍(综述)

创作:fang fang 审核:mildbreeze 12月01日
恰当的营养摄入可能降低老年人患认知障碍和痴呆的风险;
特定营养素(叶酸等B族维生素、类黄酮等抗氧化剂、维生素D和n-3脂肪酸等)和食物类别(鱼和海鲜、蔬菜、水果和适量的酒精、咖啡和茶等),可能对老年人认知功能有保护性作用,尤其是缺乏特定营养或遗传易感的个体;
饱和/反式脂肪和胆固醇的影响仍不明确;
健康饮食模式(地中海饮食、得舒饮食、北欧饮食等)的保护性作用,比单独的营养素和食物类别,有更高的证据强度。
延伸阅读
The Lancet Neurology [IF:27.138]

Nutrition and prevention of cognitive impairment

营养和认知障碍的预防

09-20, Review, 10.1016/S1474-4422(18)30338-7more

Abstract:
Nutrition is an important lifestyle factor that can modify the risk of future cognitive impairment and dementia. Some, but not conclusive, evidence (mostly from observational studies and infrequently from clinical trials) exists of a protective association between certain nutrients (eg, folate, flavonoids, vitamin D, and certain lipids) or food groups (eg, seafood, vegetables, and fruits, and potentially moderate alcohol and caffeine consumption) and cognitive outcomes in older people. For some nutrients and food groups, protection might be greater in individuals with either deficiencies in certain nutrients or a genetic predisposition to cognitive impairment. Identification of potentially different associations between such subgroups should be a priority for future research. At present, evidence of an association between nutrition and cognitive outcomes is somehow stronger for healthy dietary patterns, such as the Mediterranean-type diet, than for individual nutrients and food groups, possibly because of the cumulative beneficial effects of the many ingredients in these diets. Multidomain interventions (including a nutrition component) might also hold some promise for the prevention of cognitive impairment and dementia, but their effectiveness is still uncertain. Use of advanced technologies for nutrition assessment (eg, metabolomics and innovative methods of dietary intake assessment) and recently identified biomarkers of nutrition and neurobiological outcomes will be important to achieve this goal.

First Authors:
Nikolaos Scarmeas

Correspondence Authors:
Nikolaos Scarmeas

All Authors:
Nikolaos Scarmeas,Costas A Anastasiou,Mary Yannakoulia