赵立平+彭永德+张晨虹等:膳食纤维治疗2型糖尿病,多亏关键肠道菌

2型糖尿病患者随机分成两组,均用阿卡波糖治疗,U组(16例)为常规治疗组,W组(27例)接受同等热量的高膳食纤维营养干预;
相比U组,W组的糖化血红蛋白等指标改善得更快更好,该临床效果可经粪菌移植在小鼠中重现;
治疗过程中患者肠道菌群结构改变,高膳食纤维富集了由15株乙酸和丁酸产生菌组成的功能群,抑制了吲哚和硫化氢产生菌;
这组菌尤其增加丁酸生成,促进GLP-1和PYY分泌改善血糖,其丰度和多样性与临床治疗效果显著相关。
延伸阅读
Science [IF:41.058]

Gut bacteria selectively promoted by dietary fibers alleviate type 2 diabetes

膳食纤维选择性富集的肠道细菌可缓解2型糖尿病

2018-03-09, Article, 10.1126/science.aao5774more

Abstract:
The gut microbiota benefits humans via short-chain fatty acid (SCFA) production from carbohydrate fermentation, and deficiency in SCFA production is associated with type 2 diabetes mellitus (T2DM). We conducted a randomized clinical study of specifically designed isoenergetic diets, together with fecal shotgun metagenomics, to show that a select group of SCFA-producing strains was promoted by dietary fibers and that most other potential producers were either diminished or unchanged in patients with T2DM. When the fiber-promoted SCFA producers were present in greater diversity and abundance, participants had better improvement in hemoglobin A1c levels, partly via increased glucagon-like peptide-1 production. Promotion of these positive responders diminished producers of metabolically detrimental compounds such as indole and hydrogen sulfide. Targeted restoration of these SCFA producers may present a novel ecological approach for managing T2DM.

First Authors:
Liping Zhao1,3†*, Feng Zhang1†, Xiaoying Ding2†, Guojun Wu1†, Yan Y Lam3†,

Correspondence Authors:
Liping Zhao1,3†*, Yongde Peng2*, Chenhong Zhang1*

All Authors:
Liping Zhao,Feng Zhang,Xiaoying Ding,Guojun Wu,Yan Y Lam,Xuejiao Wang,Huaqing Fu,Xinhe Xue,Chunhua Lu,Jilin Ma,Lihua Yu,Chengmei Xu,Zhongying Ren,Ying Xu,Songmei Xu,Hongli Shen,Xiuli Zhu,Yu Shi,Qingyun Shen,Weiping Dong,Rui Liu,Yunxia Ling,Yue Zeng,Xingpeng Wang,Qianpeng Zhang,Jing Wang,Linghua Wang,Yanqiu Wu,Benhua Zeng,Hong Wei,Menghui Zhang,Yongde Peng,Chenhong Zhang