赵立平等:研究肠道菌群,注意雌雄有别!

创作:女巫 审核:沈志勋 2017年09月21日
肥胖与焦虑和抑郁等情绪障碍的高发病率相关,压力和高脂饮食均可改变肠道菌群,并有助于肥胖;
肥胖和压力对焦虑类行为、活动水平和肠道菌群组成的影响有明显的性别差异;
雄性小鼠更容易受到高脂饮食对焦虑作用的影响,肥胖雄性小鼠应对压力时表现出自发性活动下降,而肥胖雌性小鼠则没有;
在雌性小鼠中,压力导致瘦小鼠的肠道菌群与肥胖小鼠更相似;
在肠道菌群对肥胖相关情绪障碍作用的研究中,应重视性别作为生物学变量的重要性。
延伸阅读
Scientific Reports [IF:4.122]

Gender-based differences in host behavior and gut microbiota composition in response to high fat diet and stress in a mouse model

在小鼠模型中基于性别的宿主行为和肠道菌群组成的对高脂饮食和压力的反应差异

2017-09-07, Article, 10.1038/s41598-017-11069-4more

Abstract:
Obesity is associated with a high prevalence of mood disorders such as anxiety and depression. Both stress and high fat diet can alter the gut microbiota and contribute to obesity. To examine the interrelationships between obesity, stress, gut microbiota and mood disorders, obesity was induced in mice using a high fat diet, and the mice were subsequently stressed using a chronic unpredictable mild stress protocol. During the experiment, the composition of the gut microbiota was analyzed by 16 S rRNA gene high-throughput sequencing, and anxiety-like behaviors were measured. The results revealed distinct gender differences in the impacts of obesity and stress on anxiety-like behaviors, activity levels, and composition of the gut microbiota. Male mice were more vulnerable to the anxiogenic effects of the high fat diet, and obese male mice showed decreased locomotion activity in response to stress whereas obese female mice did not. In females, stress caused the gut microbiota of lean mice to more closely resemble that of obese mice. Taken together, these results suggest the importance of considering gender as a biological variable in studies on the role of gut microbiota in obesity-related mood disorders.

First Authors:
Laura C Bridgewater

Correspondence Authors:
Liping Zhao

All Authors:
Laura C Bridgewater,Chenhong Zhang,Yanqiu Wu,Weiwei Hu,Qianpeng Zhang,Jing Wang,Shengtian Li,Liping Zhao