流感疫苗或可减少孕期流感风险

创作:郭兵兵 审核:Epi汪 02月01日
在2010-2016年间,纳入包括澳洲、加拿大、美国、以色列等地的19450位因急性呼吸道或发热性疾病(ARFI)住院的孕妇,只有1030名孕妇进行了流感病毒的检测;
其中598名(58%)孕妇检测流感病毒A或B型阳性;
分别有13%的流感阳性孕妇和22%的流感阴性孕妇接种了流感疫苗;
调整了地区、季节等因素后,流感疫苗保护怀孕期间与流感相关的住院治疗的有效性约为40%;
流感疫苗可以适当保护孕妇孕期的流感风险。
延伸阅读

Influenza Vaccine Effectiveness in Preventing Influenza-associated Hospitalizations During Pregnancy: A Multi-country Retrospective Test Negative Design Study, 2010-2016

流感疫苗预防怀孕期间与流感相关的住院治疗的有效性:2010-2016年间多国参与的回顾性检测阴性设计研究

10.1093/cid/ciy737

2018-10-11, Article

Abstract & Authors:展开

Abstract:收起
Background: To date, no study has examined influenza vaccine effectiveness (IVE) against laboratory-confirmed influenza-associated hospitalizations during pregnancy.
Methods: The Pregnancy Influenza Vaccine Effectiveness Network (PREVENT) consisted of public health or healthcare systems with integrated laboratory, medical, and vaccination records in Australia, Canada (Alberta and Ontario), Israel, and the United States (California, Oregon, and Washington). Sites identified pregnant women aged 18 through 50 years whose pregnancies overlapped with local influenza seasons from 2010 through 2016. Administrative data were used to identify hospitalizations with acute respiratory or febrile illness (ARFI) and clinician-ordered real-time reverse transcription polymerase chain reaction (rRT-PCR) testing for influenza viruses. Overall IVE was estimated using the test-negative design and adjusting for site, season, season timing, and high-risk medical conditions.
Results: Among 19450 hospitalizations with an ARFI discharge diagnosis (across 25 site-specific study seasons), only 1030 (6%) of the pregnant women were tested for influenza viruses by rRT-PCR. Approximately half of these women had pneumonia or influenza discharge diagnoses (54%). Influenza A or B virus infections were detected in 598/1030 (58%) of the ARFI hospitalizations with influenza testing. Across sites and seasons, 13% of rRT-PCR-confirmed influenza-positive pregnant women were vaccinated compared with 22% of influenza-negative pregnant women; the adjusted overall IVE was 40% (95% confidence interval = 12%-59%) against influenza-associated hospitalization during pregnancy.
Conclusion: Between 2010 and 2016, influenza vaccines offered moderate protection against laboratory-confirmed influenza-associated hospitalizations during pregnancy, which may further inform the benefits of maternal influenza vaccination programs.

First Authors:
Mark G Thompson

Correspondence Authors:
Mark G Thompson

All Authors:
Mark G Thompson,Jeffrey C Kwong,Annette K Regan,Mark A Katz,Steven J Drews,Eduardo Azziz-Baumgartner,Nicola P Klein,Hannah Chung,Paul V Effler,Becca S Feldman,Kimberley Simmonds,Brandy E Wyant,Fatimah S Dawood,Michael L Jackson,Deshayne B Fell,Avram Levy,Noam Barda,Lawrence W Svenson,Rebecca V Fink,Sarah W Ball,Allison Naleway,