Nature子刊:神药二甲双胍治疗二型糖尿病,靠改变肠道菌群?
  • 二甲双胍广泛用于治疗二型糖尿病,但其机制尚不明确,有研究表明肠道菌群是其发挥功能的部位;
  • 随机双盲试验中,二甲双胍治疗初治二型糖尿病患者4个月后,对肠道菌群有很强的影响;
  • 安慰剂组转换成二甲双胍继续治疗2个月后,对其肠道菌群影响也很大;
  • 将二甲双胍治疗后的粪便菌群移植给无菌小鼠,小鼠葡萄糖耐受得到改善;
  • 二甲双胍影响来自两个不同门的细菌的生物功能,并调节菌群编码金属蛋白和金属转运蛋白基因的表达。
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Nature Medicine [IF:30.641]

Metformin alters the gut microbiome of individuals with treatment-naive type 2 diabetes, contributing to the therapeutic effects of the drug

二甲双胍通过改变初治二型糖尿病患者肠道菌群而达到治疗效果

10.1038/nm.4345

2017-05-22, Article

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Metformin is widely used in the treatment of type 2 diabetes (T2D), but its mechanism of action is poorly defined. Recent evidence implicates the gut microbiota as a site of metformin action. In a double-blind study, we randomized individuals with treatment-naive T2D to placebo or metformin for 4 months and showed that metformin had strong effects on the gut microbiome. These results were verified in a subset of the placebo group that switched to metformin 6 months after the start of the trial. Transfer of fecal samples (obtained before and 4 months after treatment) from metformin-treated donors to germ-free mice showed that glucose tolerance was improved in mice that received metformin-altered microbiota. By directly investigating metformin-microbiota interactions in a gut simulator, we showed that metformin affected pathways with common biological functions in species from two different phyla, and many of the metformin-regulated genes in these species encoded metalloproteins or metal transporters. Our findings provide support for the notion that altered gut microbiota mediates some of metformin's antidiabetic effects.

First Authors:
Hao Wu,Eduardo Esteve

Correspondence Authors:
José Manuel Fernández-Real,Fredrik Bäckhed

All Authors:
Hao Wu,Eduardo Esteve,Valentina Tremaroli,Muhammad Tanweer Khan,Robert Caesar,Louise Mannerås-Holm,Marcus Ståhlman,Lisa M Olsson,Matteo Serino,Mercè Planas-Fèlix,Gemma Xifra,Josep M Mercader,David Torrents,Rémy Burcelin,Wifredo Ricart,Rosie Perkins,José Manuel Fernández-Real,Fredrik Bäckhed

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