儿童过敏、湿疹和哮喘与肠道菌群的关联(综述)

创作:方芳 审核:李丹宜 01月11日
系统综述47项含3千多名过敏、湿疹或哮喘儿童的肠道菌群研究;
过敏、湿疹或哮喘的发生与拟杆菌科、梭菌科和肠杆菌科的相对丰度较高,双歧杆菌科和乳杆菌科相对丰度较低有关;
部分儿童的过敏性疾病与肠道菌群多样性较低有关,特定微生物的影响可能比多样性更重要;
过敏或哮喘的6月龄婴儿肠道念珠菌和红酵母属丰度较高;
肠道菌群组成与过敏性疾病的关联在年龄较大儿童中的一致性不如新生儿,早期微生物暴露可能起更重要的作用。
延伸阅读

Association between the intestinal microbiota and allergic sensitization, eczema, and asthma: A systematic review

肠道微生物群与变应性致敏、湿疹和哮喘之间的关联:系统综述

2018-12-29, Article, 10.1016/j.jaci.2018.09.025more

Abstract:
The intestinal microbiota plays an important role in development of the immune system and regulation of immune responses. This review summarizes the association between the intestinal microbiota and the development of allergic sensitization, eczema, and asthma in neonates and children. Overall, a greater relative abundance of Bacteroidaceae, Clostridiaceae, and Enterobacteriaceae and a lower relative abundance of Bifidobacteriaceae and Lactobacillaceae is associated with the development of allergic sensitization, eczema, or asthma. Reduced bacterial diversity can be associated with the development of allergic disease. The association between the composition of the intestinal microbiota and the development of allergic disease or asthma is less consistent in older children than in neonates, suggesting that early-life microbial exposure plays a more important role. Inconsistencies in the results reported from different studies might partly be explained by heterogeneity in design, study populations, diagnostic criteria, microbiota analysis methods, and reporting on different taxonomic levels. Larger studies that better account for antenatal and postnatal factors will further help determine specific microbial intestinal signatures associated with increased risk of allergy and asthma. This will enable the early identification of infants at high risk and facilitate novel strategies and interventions to prevent and treat these conditions, including modifying the intestinal microbiota early in life.

First Authors:
Petra Zimmermann

Correspondence Authors:
Petra Zimmermann

All Authors:
Petra Zimmermann,Nicole Messina,William W Mohn,B Brett Finlay,Nigel Curtis