Nature子刊:分娩方式影响婴儿早期的肠道菌群定殖及免疫功能

创作:米见对 审核:沈志勋 12月06日
对16名母亲的粪便及产道菌群、及33名新生婴儿的粪便菌群进行分析;
拟杆菌门及放线菌门中的23个分类群(主要包括拟杆菌属及双歧杆菌属菌株)仅可在顺产母亲传递给婴儿的肠道菌群中鉴定出;
顺产婴儿肠道中脂多糖(LPS)合成与膜转运途径的富集与从母亲获得的上述特定菌株有关;
LPS可刺激免疫系统,在体外及体内均可引起TNF-α和IL-18的升高;
剖腹产可能破坏母亲向婴儿的菌株纵向传递,从而影响后代的免疫功能。
延伸阅读
Nature Communications [IF:12.353]

Birth mode is associated with earliest strain-conferred gut microbiome functions and immunostimulatory potential

分娩方式与最早定殖的菌株赋予的肠道菌群功能和免疫刺激潜力相关

11-30, Article, 10.1038/s41467-018-07631-xmore

Abstract:
The rate of caesarean section delivery (CSD) is increasing worldwide. It remains unclear whether disruption of mother-to-neonate transmission of microbiota through CSD occurs and whether it affects human physiology. Here we perform metagenomic analysis of earliest gut microbial community structures and functions. We identify differences in encoded functions between microbiomes of vaginally delivered (VD) and CSD neonates. Several functional pathways are over-represented in VD neonates, including lipopolysaccharide (LPS) biosynthesis. We link these enriched functions to individual-specific strains, which are transmitted from mothers to neonates in case of VD. The stimulation of primary human immune cells with LPS isolated from early stool samples of VD neonates results in higher levels of tumour necrosis factor (TNF-α) and interleukin 18 (IL-18). Accordingly, the observed levels of TNF-α and IL-18 in neonatal blood plasma are higher after VD. Taken together, our results support that CSD disrupts mother-to-neonate transmission of specific microbial strains, linked functional repertoires and immune-stimulatory potential during a critical window for neonatal immune system priming.

First Authors:
Linda Wampach,Anna Heintz-Buschart,Joëlle V Fritz

Correspondence Authors:
Paul Wilmes

All Authors:
Linda Wampach,Anna Heintz-Buschart,Joëlle V Fritz,Javier Ramiro-Garcia,Janine Habier,Malte Herold,Shaman Narayanasamy,Anne Kaysen,Angela H Hogan,Lutz Bindl,Jean Bottu,Rashi Halder,Conny Sjöqvist,Patrick May,Anders F Andersson,Carine de Beaufort,Paul Wilmes