添加益生菌的蜂蜜可改善糖尿病肾病的部分代谢指标

创作:MAY DAY 审核:沈志勋 09月28日
纳入60名糖尿病肾病(DN)患者,进行随机双盲对照临床试验,益生菌蜂蜜组给予含有凝结芽孢杆菌T11的蜂蜜,对照组给予蜂蜜;
取空腹血液样本,检测各指标;
与对照组相比,益生菌蜂蜜组病人胰岛素水平和胰岛素抵抗下降、胰岛素敏感指数升高,总胆固醇/高密度脂蛋白胆固醇比值、高敏性C反应蛋白(hs-CRP)和丙二醛(MDA)水平降低;
益生菌蜂蜜对DN病人的胰岛素代谢、脂代谢、hs-CRP和MDA水平均有益处,对其他代谢状况无影响。
延伸阅读

The Effects of Probiotic Honey Consumption on Metabolic Status in Patients with Diabetic Nephropathy: a Randomized, Double-Blind, Controlled Trial

摄入含有益生菌的蜂蜜对糖尿病肾病病人代谢状况的影响:一项随机双盲对照试验

09-14, Article, 10.1007/s12602-018-9468-xmore

Abstract:
To the best of our knowledge, this study is the first evaluating the effects of probiotic honey intake on glycemic control, lipid profiles, biomarkers of inflammation, and oxidative stress in patients with diabetic nephropathy (DN). This investigation was conducted to evaluate the effects of probiotic honey intake on metabolic status in patients with DN. This randomized, double-blind, controlled clinical trial was performed among 60 patients with DN. Patients were randomly allocated into two groups to receive either 25 g/day probiotic honey containing a viable and heat-resistant probiotic Bacillus coagulans T11 (IBRC-M10791) (10 CFU/g) or 25 g/day control honey (n = 30 each group) for 12 weeks. Fasting blood samples were taken at baseline and 12 weeks after supplementation to quantify glycemic status, lipid concentrations, biomarkers of inflammation, and oxidative stress. After 12 weeks of intervention, patients who received probiotic honey compared with the control honey had significantly decreased serum insulin levels (- 1.2 ± 1.8 vs. - 0.1 ± 1.3 μIU/mL, P = 0.004) and homeostasis model of assessment-estimated insulin resistance (- 0.5 ± 0.6 vs. 0.003 ± 0.4, P = 0.002) and significantly improved quantitative insulin sensitivity check index (+ 0.005 ± 0.009 vs. - 0.0007 ± 0.005, P = 0.004). Additionally, compared with the control honey, probiotic honey intake has resulted in a significant reduction in total-/HDL-cholesterol (- 0.2 ± 0.5 vs. + 0.1 ± 0.1, P = 0.04). Probiotic honey intake significantly reduced serum high-sensitivity C-reactive protein (hs-CRP) (- 1.9 ± 2.4 vs. - 0.2 ± 2.7 mg/L, P = 0.01) and plasma malondialdehyde (MDA) levels (- 0.1 ± 0.6 vs. + 0.6 ± 1.0 μmol/L, P = 0.002) compared with the control honey. Probiotic honey intake had no significant effects on other metabolic profiles compared with the control honey. Overall, findings from the current study demonstrated that probiotic honey consumption for 12 weeks among DN patients had beneficial effects on insulin metabolism, total-/HDL-cholesterol, serum hs-CRP, and plasma MDA levels, but did not affect other metabolic profiles.

First Authors:
Navid Mazruei Arani

Correspondence Authors:
Zahra Emam-Djomeh,Zatollah Asemi

All Authors:
Navid Mazruei Arani,Zahra Emam-Djomeh,Hamid Tavakolipour,Reza Sharafati-Chaleshtori,Alireza Soleimani,Zatollah Asemi