欧米伽3脂肪酸通过作用于肠道菌群,促进人体健康
创作:兵兵 审核:兵兵
  • 为数不多的人群研究结果表明,普拉梭菌的降低与拟杆菌、产丁酸菌的增加有关;并且,这些菌群的失调常伴有肠炎;
  • 欧米伽3多不饱和脂肪酸可以通过重新平衡肠道菌群缓解这些疾病,并产生抗炎因子,比如短链脂肪酸;
  • 此外,动物实验结果表明肠道菌群、欧米伽3脂肪酸与免疫的相互作用可以帮助维持肠壁的完整性,并与宿主免疫细胞相互作用;
  • 最后,动物和人群试验都指明,欧米伽3脂肪酸可以通过改变肠道菌群组成影响肠脑屏障。
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Impact of Omega-3 Fatty Acids on the Gut Microbiota

欧米伽3脂肪酸对于肠道菌群的影响

10.3390/ijms18122645

2017-12-07, Review

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Long-term dietary habits play a crucial role in creating a host-specific gut microbiota community in humans. Despite the many publications about the effects of carbohydrates (prebiotic fibers), the impact of dietary fats, such as omega-3 polyunsaturated fatty acids (PUFAs), on the gut microbiota is less well defined. The few studies completed in adults showed some common changes in the gut microbiota after omega-3 PUFA supplementation. In particular, a decrease in Faecalibacterium, often associated with an increase in the Bacteroidetes and butyrate-producing bacteria belonging to the Lachnospiraceae family, has been observed. Coincidentally, a dysbiosis of these taxa is found in patients with inflammatory bowel disease. Omega-3 PUFAs can exert a positive action by reverting the microbiota composition in these diseases, and increase the production of anti-inflammatory compounds, like short-chain fatty acids. In addition, accumulating evidence in animal model studies indicates that the interplay between gut microbiota, omega-3 fatty acids, and immunity helps to maintain the intestinal wall integrity and interacts with host immune cells. Finally, human and animal studies have highlighted the ability of omega-3 PUFAs to influence the gut-brain axis, acting through gut microbiota composition. From these findings, the importance of the omega-3 connection to the microbiota emerges, encouraging further studies.

First Authors:
Lara Costantini,Romina Molinari

Correspondence Authors:
Nicolò Merendino

All Authors:
Lara Costantini,Romina Molinari,Barbara Farinon,Nicolò Merendino

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