• 抗生素对菌群有深远影响,可能改变营养结构或导致病原体扩张;
  • 病原菌能利用来源于菌群的碳和氮,能调节促进自身生长和毒性的信号;
  • 通过促进炎症,病原菌改变肠道环境,利用特殊的呼吸系统和金属利用机制推动扩张;
  • 了解菌群、宿主和病原菌的关系,有助于发展操纵菌群以对抗感染性疾病的策略。
#粪菌移植# #Nature:6篇雄文,详解健康、疾病与肠道菌群!#
Nature [IF:43.07]

Interactions between the microbiota and pathogenic bacteria in the gut



2016-07-06, Review

Abstract & Authors:展开

The microbiome has an important role in human health. Changes in the microbiota can confer resistance to or promote infection by pathogenic bacteria. Antibiotics have a profound impact on the microbiota that alters the nutritional landscape of the gut and can lead to the expansion of pathogenic populations. Pathogenic bacteria exploit microbiota-derived sources of carbon and nitrogen as nutrients and regulatory signals to promote their own growth and virulence. By eliciting inflammation, these bacteria alter the intestinal environment and use unique systems for respiration and metal acquisition to drive their expansion. Unravelling the interactions between the microbiota, the host and pathogenic bacteria will produce strategies for manipulating the microbiota against infectious diseases.

First Authors:
Andreas J Bäumler

Correspondence Authors:
Vanessa Sperandio

All Authors:
Andreas J Bäumler,Vanessa Sperandio