多不饱和脂肪酸影响儿童身高发育

文章分析了400名12-59月龄的马拉维农村儿童(62%为生长迟缓)的677份血清代谢物。
低年龄别身长值(HAZ)与较低的血清ω-3/ω-6多不饱和脂肪酸(PUFA)、硫酸化神经甾体、肉碱和γ-谷酰基氨基酸浓度相关。
低HAZ与(与吸烟有关的)5个生物标志物的显著高血清浓度有关。
这项横截面研究显示:生长矮小与低的血清ω-3/ω-6PUFA浓度、低的硫酸化神经甾体和低的肉碱浓度、谷胱甘肽代谢变化及二手烟带来的血清代谢物增加有关。
延伸阅读

Low serum ω-3 and ω-6 polyunsaturated fatty acids and other metabolites are associated with poor linear growth in young children from rural Malawi

低血清ω-3和ω-6多不饱和脂肪酸及其他代谢物与马拉维农村儿童不良的线性生长相关

10.3945/ajcn.117.164384

2017-12-01, Article

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Background: Stunting affects ∼25% of children <5 y of age and is associated with impaired cognitive and motor development and increased morbidity and mortality. The pathogenesis of stunting is poorly understood.Objective: The purpose of this study was to identify altered metabolic pathways associated with child stunting.Design: We measured 677 serum metabolites using liquid chromatography-tandem mass spectrometry in a cross-sectional study of 400 Malawian children aged 12-59 mo, of whom 62% were stunted.Results: A low height-for-age z score (HAZ) was associated with lower serum concentrations of 1) ω-3 (n-3) and ω-6 (n-6) polyunsaturated fatty acids (PUFAs), 2) sulfated neurosteroids, which play a role in brain development, 3) carnitine, a conditionally essential nutrient with an important role in the carnitine shuttle for the metabolism of fatty acids and energy production, and 4) γ-glutamyl amino acids, which represent an altered γ-glutamyl cycle of glutathione metabolism. A low HAZ was associated with significantly higher serum concentrations of 5 biomarkers related to cigarette smoke exposure.Conclusions: This metabolomics study shows a cross-sectional association between stunting and low serum ω-3 and ω-6 long-chain PUFAs, which are essential for growth and development; low sulfated neurosteroids, which play a role in brain development; low carnitine, which is essential for β-oxidation of fatty acids; alterations in glutathione metabolism; and increased serum metabolites that are associated with secondhand tobacco smoke exposure. This trial was registered at www.controlled-trials.com as ISRCTN14597012.

First Authors:
Richard D Semba

Correspondence Authors:
Mark J Manary

All Authors:
Richard D Semba,Indi Trehan,Ximin Li,Norman Salem,Ruin Moaddel,M Isabel Ordiz,Kenneth M Maleta,Klaus Kraemer,Mark J Manary