Nature:肠道菌群和获得性免疫到底有何关系?
  • 黏膜的T和B细胞具有区位特异性的表型和功能;
  • 它们抑制对无害抗原的响应,加强肠黏膜屏障功能,维持免疫稳态;
  • 肠道菌群失衡,会通过T细胞活化触发多种免疫疾病;
  • 理解稳态和致病菌群与宿主相互作用的机制,有助于确定预防或调节炎症性疾病的治疗靶点,也有助于促进肿瘤免疫疗法的效率。
#Nature:6篇雄文,详解健康、疾病与肠道菌群!#
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Nature [IF:43.07]

The microbiota in adaptive immune homeostasis and disease

获得性免疫平衡和疾病中的菌群

10.1038/nature18848

2016-07-06, Review

Abstract & Authors:展开

Abstract:收起
In the mucosa, the immune system's T cells and B cells have position-specific phenotypes and functions that are influenced by the microbiota. These cells play pivotal parts in the maintenance of immune homeostasis by suppressing responses to harmless antigens and by enforcing the integrity of the barrier functions of the gut mucosa. Imbalances in the gut microbiota, known as dysbiosis, can trigger several immune disorders through the activity of T cells that are both near to and distant from the site of their induction. Elucidation of the mechanisms that distinguish between homeostatic and pathogenic microbiota-host interactions could identify therapeutic targets for preventing or modulating inflammatory diseases and for boosting the efficacy of cancer immunotherapy.

First Authors:
Kenya Honda,Dan R Littman

Correspondence Authors:
Kenya Honda,Dan R Littman

All Authors:
Kenya Honda,Dan R Littman

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