益生菌调节2型糖尿病患者的空腹血糖及血脂

创作:女巫 审核:沈志勋 09月07日
60名2型糖尿病患者随机分为两组,服用益生菌补充剂或安慰剂6周,益生菌补充剂由7种活菌株(包括乳杆菌属、双歧杆菌属及链球菌属的菌株)组成;
与对照组相比,益生菌组的空腹血糖(FPG)水平显著下降,高密度脂蛋白胆固醇(HDL-C)水平显著上升;
组内和组间对比,胰岛素、甘油三酯、总胆固醇、胰岛素抵抗和人体测量值(包括体重、腰围和体重指数)没有显著变化;
多菌株益生菌补充剂可显著降低FPG水平,但还需进一步的研究来证实。
延伸阅读

The effect of probiotic supplementation on glycemic control and lipid profile in patients with type 2 diabetes: A randomized placebo controlled trial

补充益生菌对2型糖尿病患者血糖控制和血脂水平的影响:一项随机安慰剂对照试验

08-28, Article, 10.1016/j.dsx.2018.08.008more

Abstract:
Aims: The role of gut microbiota in the pathogenesis of diabetes is increasing; this study investigates the effect of multi-strain probiotics on fasting plasma glucose (FPG), plasma insulin and lipid profile among patients.
Methods: This randomized double blind controlled trial was performed among 60 patients; individuals were randomly assigned into 2 groups of 30 participants in order to take either probiotic supplements or placebo for 6 weeks. The probiotic supplement consisted of 7 viable strains Lactobacillus, Bifidobacterium and Streptococcus. Nutrient intakes were estimated using a 3-day and 24 hour-dietary recall at the beginning and end of study. Fasting blood samples were taken before and after intervention to measure the levels of FPG, plasma insulin and lipid profiles.
Results: Within group comparisons showed significant decrease and increase in the levels of FPG (P = 0.001) and HDL-C (P = 0.002) in probiotic group, respectively. No significant alterations were observed for within and between group comparisons in the levels of insulin, triglycerides, total cholesterol, insulin resistance and anthropometric measurements, including weight, waist circumference and body mass index (all P > 0.05).
Conclusions: This study showed a significant decrease in FPG level by multi-strain probiotic supplements in within group comparison; though, further studies are needed to confirm results. (IRCT Code: IRCT2013100714925N1).

First Authors:
Elham Razmpoosh

Correspondence Authors:
Maryam Javadi

All Authors:
Elham Razmpoosh,Amir Javadi,Hanieh Sadat Ejtahed,Parvin Mirmiran,Maryam Javadi,Abbas Yousefinejad