Cell子刊:肠道也有造血细胞?

创作:女巫 审核:mildbreeze 12月06日
对21例接受肠移植的患者进行5年追踪,发现受体血液中长期存在来自供体的血细胞,源于移植物中的造血干细胞和祖细胞(HSPC);
在肠粘膜、Peyer氏结、肠系膜淋巴结和肝脏中,均检测到供体来源的HSPC;
人肠道HSPC与骨髓HSPC有相似表型,在体外和体内具有多谱系分化潜能;
源于供体的T细胞,在受体淋巴器官中进行选择,可促进移植组织的免疫耐受;
源于供体的肠道HSPC逐渐被血液循环中的受体HSPC所替代。
延伸阅读
Cell Stem Cell [IF:23.29]

Human Intestinal Allografts Contain Functional Hematopoietic Stem and Progenitor Cells that Are Maintained by a Circulating Pool

人类肠异体移植物包含由循环池维持的功能性造血干细胞和祖细胞

11-29, Article, 10.1016/j.stem.2018.11.007more

Abstract:
Human intestinal transplantation often results in long-term mixed chimerism of donor and recipient blood in transplant patients. We followed the phenotypes of chimeric peripheral blood cells in 21 patients receiving intestinal allografts over 5 years. Donor lymphocyte phenotypes suggested a contribution of hematopoietic stem and progenitor cells (HSPCs) from the graft. Surprisingly, we detected donor-derived HSPCs in intestinal mucosa, Peyer’s patches, mesenteric lymph nodes, and liver. Human gut HSPCs are phenotypically similar to bone marrow HSPCs and have multilineage differentiation potential in vitro and in vivo. Analysis of circulating post-transplant donor T cells suggests that they undergo selection in recipient lymphoid organs to acquire immune tolerance. Our longitudinal study of human HSPCs carried in intestinal allografts demonstrates their turnover kinetics and gradual replacement of donor-derived HSPCs from a circulating pool. Thus, we have demonstrated the existence of functioning HSPCs in human intestines with implications for promoting tolerance in transplant recipients.

First Authors:
Jianing Fu

Correspondence Authors:
Megan Sykes

All Authors:
Jianing Fu,Julien Zuber,Mercedes Martinez,Brittany Shonts,Aleksandar Obradovic,Hui Wang,Sai-ping Lau,Amy Xia,Elizabeth E Waffarn,Kristjana Frangaj,Thomas M Savage,Michael T Simpson,Suxiao Yang,Xinzheng V Guo,Michelle Miron,Takashi Senda,Kortney Rogers,Adeeb Rahman,Siu-hong Ho,Yufeng Shen,Adam Griesemer,Donna L Farber,Tomoaki Kato,Megan Sykes