VMH——整合人体和肠道菌群的代谢数据库

VMH整合了人类代谢、肠道菌群、疾病、营养和ReconMaps五类资源,基于代谢物、生化反应和基因的共享的命名和数据库条目,实现资源的相互关联;
可结合人类和肠道菌群重建代谢模型;
网站可实现数据查询、浏览、通路图可视化和饮食方案设计4大功能,关键字还可链接至外部57个数据库;
还开发了程序调用接口,方便编程批量查询和其它程序调用;
该数据库有助于生物医学相关人员进行饮食设计、组学数据解析和提出科学假设。
延伸阅读

The Virtual Metabolic Human database: integrating human and gut microbiome metabolism with nutrition and disease

人类虚拟代谢数据库VHM——整合人类和肠道菌群与营养和疾病

10-29, Article, 10.1093/nar/gky992more

Abstract:
A multitude of factors contribute to complex diseases and can be measured with 'omics' methods. Databases facilitate data interpretation for underlying mechanisms. Here, we describe the Virtual Metabolic Human (VMH, www.vmh.life) database encapsulating current knowledge of human metabolism within five interlinked resources 'Human metabolism', 'Gut microbiome', 'Disease', 'Nutrition', and 'ReconMaps'. The VMH captures 5180 unique metabolites, 17 730 unique reactions, 3695 human genes, 255 Mendelian diseases, 818 microbes, 632 685 microbial genes and 8790 food items. The VMH's unique features are (i) the hosting of the metabolic reconstructions of human and gut microbes amenable for metabolic modeling; (ii) seven human metabolic maps for data visualization; (iii) a nutrition designer; (iv) a user-friendly webpage and application-programming interface to access its content; (v) user feedback option for community engagement and (vi) the connection of its entities to 57 other web resources. The VMH represents a novel, interdisciplinary database for data interpretation and hypothesis generation to the biomedical community.

First Authors:
Alberto Noronha

Correspondence Authors:
Ronan M T Fleming,Ines Thiele

All Authors:
Alberto Noronha,Jennifer Modamio,Yohan Jarosz,Elisabeth Guerard,Nicolas Sompairac,German Preciat,Anna Dröfn Daníelsdóttir,Max Krecke,Diane Merten,Hulda S Haraldsdóttir,Almut Heinken,Laurent Heirendt,Stefanía Magnúsdóttir,Dmitry A Ravcheev,Swagatika Sahoo,Piotr Gawron,Lucia Friscioni,Beatriz Garcia,Mabel Prendergast,Alberto Puente,Mariana Rodrigues,Akansha Roy,Mouss Rouquaya,Luca Wiltgen,Alise Žagare,Elisabeth John,Maren Krueger,Inna Kuperstein,Andrei Zinovyev,Reinhard Schneider,Ronan M T Fleming,Ines Thiele