• 肠菌调节病毒特异性CD4CD8T细胞反应及抗体反应;新霉素敏感型菌参与诱导肺部获得性免疫反应;抗生素饲喂后Toll样受体配体对免疫损伤予以辅助;完整的肠道菌群提供信号促使IL-1β前体和IL-18前体mRNA表达;感染后炎性因子激活会促使树突细胞从肺部迁移向引流淋巴结及T细胞分化
PNAS [IF:9.58]

Microbiota regulates immune defense against respiratory tract influenza A virus infection



2011-03-14, Article

Abstract & Authors:展开

Although commensal bacteria are crucial in maintaining immune homeostasis of the intestine, the role of commensal bacteria in immune responses at other mucosal surfaces remains less clear. Here, we show that commensal microbiota composition critically regulates the generation of virus-specific CD4 and CD8 T cells and antibody responses following respiratory influenza virus infection. By using various antibiotic treatments, we found that neomycin-sensitive bacteria are associated with the induction of productive immune responses in the lung. Local or distal injection of Toll-like receptor (TLR) ligands could rescue the immune impairment in the antibiotic-treated mice. Intact microbiota provided signals leading to the expression of mRNA for pro-IL-1β and pro-IL-18 at steady state. Following influenza virus infection, inflammasome activation led to migration of dendritic cells (DCs) from the lung to the draining lymph node and T-cell priming. Our results reveal the importance of commensal microbiota in regulating immunity in the respiratory mucosa through the proper activation of inflammasomes.

First Authors:
Takeshi Ichinohe,Iris K Pang

Correspondence Authors:
Akiko Iwasaki

All Authors:
Takeshi Ichinohe,Iris K Pang,Yosuke Kumamoto,David R Peaper,John H Ho,Thomas S Murray,Akiko Iwasaki