Nature子刊:怀孕后女性阴道菌群到底怎么变?可能和种族还有关
创作:Epi汪 审核:Epi汪 06月01日
  • 采集613名怀孕和1969名非怀孕女性阴道拭子,提示孕期阴道菌群α多样性低,四种常见乳酸杆菌丰度较高,尤其是惰性乳杆菌;
  • 上述改变规律在非洲裔妇女中更为明显,而欧洲、西班牙血统的女性变化较小;
  • 随访怀孕女性的妊娠期阴道菌群变化,非裔女性妊娠早期到晚期菌型变化波动更大;
  • 妊娠期阴道菌群变化有律可循,孕早期以卷曲乳杆菌主导的菌型最为稳定;
  • 妊娠早期阴道菌群功能即发生变化;
  • 阴道G.vaginalis菌株在不同种族女性中存在差异。
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Nature Medicine [IF:30.641]

Racioethnic diversity in the dynamics of the vaginal microbiome during pregnancy

不同种族的妊娠期女性阴道菌群的动态规律

10.1038/s41591-019-0465-8

05-29, Article

Abstract & Authors:展开

Abstract:收起
The microbiome of the female reproductive tract has implications for women’s reproductive health. We examined the vaginal microbiome in two cohorts of women who experienced normal term births: a cross-sectionally sampled cohort of 613 pregnant and 1,969 non-pregnant women, focusing on 300 pregnant and 300 non-pregnant women of African, Hispanic or European ancestry case-matched for race, gestational age and household income; and a longitudinally sampled cohort of 90 pregnant women of African or non-African ancestry. In these women, the vaginal microbiome shifted during pregnancy toward Lactobacillus-dominated profiles at the expense of taxa often associated with vaginal dysbiosis. The shifts occurred early in pregnancy, followed predictable patterns, were associated with simplification of the metabolic capacity of the microbiome and were significant only in women of African or Hispanic ancestry. Both genomic and environmental factors are likely contributors to these trends, with socioeconomic status as a likely environmental influence.

First Authors:
Myrna G Serrano,Hardik I Parikh

Correspondence Authors:
Gregory A Buck

All Authors:
Myrna G Serrano,Hardik I Parikh,J Paul Brooks,David J Edwards,Tom J Arodz,Laahirie Edupuganti,Bernice Huang,Philippe H Girerd,Yahya A Bokhari,Steven P Bradley,Jamie L Brooks,Molly R Dickinson,Jennifer I Drake,Robert A Duckworth III,Stephen S Fong,Abigail L Glascock,Sophonie Jean,Nicole R Jimenez,Joseph Khoury,Vishal N Koparde,Ana M Lara,Vladimir Lee,Andrey V Matveyev,Sarah H Milton,Shreni D Mistry,Sarah K Rozycki,Nihar U Sheth,Ekaterina Smirnova,Stephany C Vivadelli,N Romesh Wijesooriya,Jie Xu,Ping Xu,Donald O Chaffin,Amber L Sexton,Michael G Gravett,Craig E Rubens,Karen D Hendricks-Muñoz,Kimberly K Jefferson,Jerome F Strauss III,Jennifer M Fettweis,Gregory A Buck

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