Nature子刊:肠道菌群如何影响心理健康?

创作:小肠 审核:小肠 02月11日
纳入1054名参与者,分析肠道菌群与抑郁以及生活质量的关系,得到的结果在另外1070名参与者中进行验证,证明肠道菌群与心理健康具有重要联系;
产丁酸的粪杆菌属和粪球菌属,始终与较高的生活质量相关;
在排除抗抑郁药物的影响后,小杆菌属和粪球菌属在抑郁人群中呈现减少的趋势;
肠道细菌合成多巴胺代谢物——3,4-二羟苯酰乙酸的能力,与良好的心理健康状态呈正相关;
肠道细菌产生的γ-氨基丁酸,可能与抑郁状态有关。
延伸阅读
Nature Microbiology [IF:14.174]

The neuroactive potential of the human gut microbiota in quality of life and depression

人类肠道菌群潜在的神经活性对生活质量和抑郁的影响

02-04, Article, 10.1038/s41564-018-0337-xmore

Abstract:
The relationship between gut microbial metabolism and mental health is one of the most intriguing and controversial topics in microbiome research. Bidirectional microbiota-gut-brain communication has mostly been explored in animal models, with human research lagging behind. Large-scale metagenomics studies could facilitate the translational process, but their interpretation is hampered by a lack of dedicated reference databases and tools to study the microbial neuroactive potential. Surveying a large microbiome population cohort (Flemish Gut Flora Project, n = 1,054) with validation in independent data sets (n = 1,070), we studied how microbiome features correlate with host quality of life and depression. Butyrate-producing Faecalibacterium and Coprococcus bacteria were consistently associated with higher quality of life indicators. Together with Dialister, Coprococcus spp. were also depleted in depression, even after correcting for the confounding effects of antidepressants. Using a module-based analytical framework, we assembled a catalogue of neuroactive potential of sequenced gut prokaryotes. Gut-brain module analysis of faecal metagenomes identified the microbial synthesis potential of the dopamine metabolite 3,4-dihydroxyphenylacetic acid as correlating positively with mental quality of life and indicated a potential role of microbial γ-aminobutyric acid production in depression. Our results provide population-scale evidence for microbiome links to mental health, while emphasizing confounder importance.

First Authors:
Sara Vieira-Silva,Jeroen Raes

Correspondence Authors:
Jeroen Raes

All Authors:
Mireia Valles-Colomer,Gwen Falony,Youssef Darzi,Ettje F Tigchelaar,Jun Wang,Raul Y Tito,Carmen Schiweck,A Kurilshikov,Marie Joossens,Cisca Wijmenga,Stephan Claes,Lukas Van Oudenhove,Alexandra Zhernakova,Sara Vieira-Silva,Jeroen Raes