动物:从抗炎看富多酚绿茶的减肥机制

创作:女巫 审核:JIAN 剑 07月11日
肥胖导致脂肪组织中miRNA表达的变化,并且这种调节与疾病的病理生理学相关。
绿茶(GT)是天然的多酚来源,可预防代谢性疾病。
GT治疗(500mg/bw,12周)促进高脂饮食小鼠能量消耗;体重增加减少;肥胖、炎症和胰岛素敏感性改善;这些表型与脂肪组织中miR-335表达降低相关。
miR-335在脂肪细胞中被TNF-α上调,进而下调参与胰岛素信号传导和脂质代谢的基因;而GT可抑制TNF-α的作用。
延伸阅读

Polyphenol-rich green tea extract improves adipose tissue metabolism by down-regulating miR-335 expression and mitigating insulin resistance and inflammation

富含多酚的绿茶提取物通过下调miR-335表达和减轻胰岛素抵抗和炎症来改善脂肪组织代谢

04-07, Article, 10.1016/j.jnutbio.2018.03.024more

Abstract:
Obesity leads to changes in miRNA expression in adipose tissue, and this modulation is linked to the pathophysiology of the disease. Green tea (GT) is a natural source of polyphenols that have been shown to confer health benefits, particularly preventing metabolic diseases. Here, we investigated if the beneficial effects of GT in obesity results from changes in the miRNA profile in white adipose tissue. GT treatment [500 mg/body weight (BW)/12 weeks] increased energy expenditure of high-fat diet-fed mice (16 weeks), leading to reduced weight gain, decreased adiposity, reduced inflammation and improved insulin sensitivity. These phenotypes were associated with a decrease in the expression of miR-335 in the adipose tissue. miR-335 was up-regulated by TNF-α in adipocytes and, in turn, down-regulated genes involved in insulin signaling and lipid metabolism. On the other hand, GT inhibited TNF-α effect. In conclusion, miR-335 serves as a link between inflammation and impaired metabolism in adipose tissue, providing an important mechanistic insight into the molecular basis underlying GT action during obesity.

First Authors:
Rosemari Otton

Correspondence Authors:
Rosemari Otton

All Authors:
Rosemari Otton,Anaysa Paola Bolin,Leticia Torres Ferreira,Marcelo Paradiso Marinovic,Andrea Livia Silva Rocha,Marcelo Alves Mori