Nature子刊:化友为敌——TGFβ/BMP免疫信号异常导致共生菌群失调

创作:小肠 审核:小肠君 02月11日
宿主基因和肠道菌群的互作是肠道菌群稳态的基础,这一互作通路的异常会改变共生菌群的致病性;
TGFβ/骨形成蛋白(BMP)发生突变的免疫缺陷型秀丽隐杆线虫中,肠杆菌属的细菌显著增殖;
TGFβ/BMP免疫信号通路对菌群的调控主要发生在前肠部位,该作用依赖于多种组织共同参与;
肠杆菌属是线虫肠道中的常见共生细菌,正常情况下提供定殖抗性、抵御肠道感染;
TGFβ/BMP 信号通路的异常,会将有益的肠杆菌转化为致病菌。
延伸阅读
Nature Communications [IF:12.353]

TGFβ/BMP immune signaling affects abundance and function of C. elegans gut commensals

TGFβ/骨形成蛋白免疫信号影响秀丽隐杆线虫肠道共生菌的丰度和功能

02-05, Article, 10.1038/s41467-019-08379-8more

Abstract:
The gut microbiota contributes to host health and fitness, and imbalances in its composition are associated with pathology. However, what shapes microbiota composition is not clear, in particular the role of genetic factors. Previous work in Caenorhabditis elegans defined a characteristic worm gut microbiota significantly influenced by host genetics. The current work explores the role of central regulators of host immunity and stress resistance, employing qPCR and CFU counts to measure abundance of core microbiota taxa in mutants raised on synthetic communities of previously-isolated worm gut commensals. This revealed a bloom, specifically of Enterobacter species, in immune-compromised TGFβ/BMP mutants. Imaging of fluorescently labeled Enterobacter showed that TGFβ/BMP-exerted control operated primarily in the anterior gut and depended on multi-tissue contributions. Enterobacter commensals are common in the worm gut, contributing to infection resistance. However, disruption of TGFβ/BMP signaling turned a normally beneficial Enterobacter commensal to pathogenic. These results demonstrate specificity in gene-microbe interactions underlying gut microbial homeostasis and highlight the pathogenic potential of their disruption.

First Authors:
Maureen Berg

Correspondence Authors:
Michael Shapira

All Authors:
Maureen Berg,David Monnin,Juhyun Cho,Lydia Nelson,Alex Crits-Christoph,Michael Shapira