创作:小肠 审核:小肠君 03月01日
  • 从11850个人类肠道菌群基因组中,鉴别出1952种潜在的、未被培养的肠道细菌;
  • 这些潜在细菌,将已知肠道细菌的总种类数量增加了281% ;
  • 新发现的细菌在欧美人群中并不普遍,但却极大地丰富了对非洲、南美人群肠道细菌种类的了解,对已知细菌种类的增幅超过200%;
  • 潜在细菌的基因组上存在上百种新的生物合成基因簇,可能在宿主中发挥特殊作用;
  • 潜在细菌的基因组的发现,显著增加了对肠道菌群种类和功能的了解。
Nature [IF:43.07]

A new genomic blueprint of the human gut microbiota



02-11, Article

Abstract & Authors:展开

The human gut microbiota composition is linked to health and disease, but knowledge of individual microbial species is needed to decipher their biological role. Despite extensive culturing and sequencing efforts, the complete bacterial repertoire of the human gut microbiota remains undefined. Here we identify 1,952 uncultured candidate bacterial species by reconstructing 92,143 metagenome-assembled genomes from 11,850 human gut microbiomes. These uncultured genomes substantially expand the known species repertoire of the collective human gut microbiota, with a 281% increase in phylogenetic diversity. Although the newly identified species are less prevalent in well-studied populations compared to reference isolate genomes, they improve classification of understudied African and South American samples by over 200%. These candidate species encode hundreds of novel biosynthetic gene clusters and possess a distinctive functional capacity that might explain their elusive nature. Our work uncovers the uncultured gut bacterial diversity, providing unprecedented resolution for taxonomic and functional characterization of the intestinal microbiota.

First Authors:
Alexandre Almeida

Correspondence Authors:
Alexandre Almeida,Robert D Finn

All Authors:
Alexandre Almeida,Alex L Mitchell,Miguel Boland,Samuel Forster,Gregory B Gloor,Aleksandra Tarkowska,Trevor D Lawley,Robert D Finn