食品添加剂与儿童克罗恩病有关吗?
  • 食品添加剂可能会促进克罗恩病发病。
  • 为了研究克罗恩病儿童的食品添加剂摄入,通过3*24小时的饮食回顾,评估疾病特征、饮食摄入和种类组成。
  • 记录的1325种食物中,黄原胶、卡拉胶、麦芽糊精和大豆卵磷脂日均摄入量分别为0.96±0.72,0.58±0.63,0.95±0.77和0.90±0.74。
  • 在8种检测的添加剂中,受试者日均摄入的添加剂量和种类分别为为3.6±2.1和2.4±1种。
  • 结果表明,克罗恩病的儿童经常食用食品添加剂;其对病程的影响有待进一步研究。
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Children with Crohn's Disease Frequently Consume Select Food Additives

克罗恩病的儿童经常消费选择食品添加剂

10.1007/s10620-018-5145-x

2018-06-04, Article

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OBJECTIVE: Certain food additives may promote the pathogenesis of Crohn's disease (CD), but thus far the evaluation of food additive exposures in humans has been limited. The objective of this study was to quantify food additive exposures in children with CD.
METHODS: In a trial for bone health in CD, children were followed over 24 months with evaluation of disease characteristics, dietary intake, and body composition. At baseline, participants completed three 24-h dietary recalls. Foods were categorized, and the ingredient list for each item was evaluated for the presence of select food additives: polysorbate-80, carboxymethylcellulose, xanthan gum, soy lecithin, titanium dioxide, carrageenan, maltodextrin, and aluminosilicates. The frequency of exposures to these food additives was described for study participants and for food categories.
RESULTS: At study baseline, 138 participants, mean age 14.2 ± 2.8 years, 95% having inactive or mild disease, were enrolled and dietary recalls were collected. A total of 1325 unique foods were recorded. Mean exposures per day for xanthan gum was 0.96 ± 0.72, carrageenan 0.58 ± 0.63, maltodextrin 0.95 ± 0.77, and soy lecithin 0.90 ± 0.74. The other additives had less than 0.1 exposures per day. For the 8 examined food additives, participants were exposed to a mean (SD) of 3.6 ± 2.1 total additives per recall day and a mean (SD) of 2.4 ± 1.0 different additives per day.
CONCLUSION: Children with CD frequently consume food additives, and the impact on disease course needs further study.

First Authors:
Dale Lee

Correspondence Authors:
Dale Lee

All Authors:
Dale Lee,C Kaiulani Swan,David Suskind,Ghassan Wahbeh,Jairam Vanamala,Robert N Baldassano,Mary B Leonard,Johanna W Lampe

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