芽孢杆菌发酵的绿茶为什么能够降脂减肥?

创作:女巫 审核:yingjian 2017年09月25日
之前的研究发现,芽孢杆菌发酵的绿茶(FGT)具有降脂减肥功效,本文考察其作用机制。
减少脂肪消化吸收:FGT能有效抑制体外胰脂酶活性;改善大鼠餐后脂血症,并显著降低仓鼠餐后血浆甘油三酯水平。
增加能量消耗:小鼠持续2周食用FGT,通过诱导血浆5-羟色胺增加22%的能量消耗(5-羟色胺是调节能量消耗和外周组织中脂质代谢基因mRNA表达的神经递质)。
调节肠道菌群:FGT减少仓鼠厚壁菌门的比例,这可能进一步解释其减肥作用。
延伸阅读

Fermented green tea extract exhibits hypolipidaemic effects through the inhibition of pancreatic lipase and promotion of energy expenditure

发酵绿茶提取物通过抑制胰脂酶和促进能量消耗降低血脂

10.1017/S0007114516004621

2017-01-01, Article

Abstract & Authors:展开

Abstract:收起
Hyperlipidaemia is a major cause of atherosclerosis and related CVD and can be prevented with natural substances. Previously, we reported that a novel Bacillus-fermented green tea (FGT) exerts anti-obesity and hypolipidaemic effects. This study further investigated the hypotriglyceridaemic and anti-obesogenic effects of FGT and its underlying mechanisms. FGT effectively inhibited pancreatic lipase activity in vitro (IC50, 0·48 mg/ml) and ameliorated postprandial lipaemia in rats (26 % reduction with 500 mg/kg FGT). In hypertriglyceridaemic hamsters, FGT administration significantly reduced plasma TAG levels. In mice, FGT administration (500 mg/kg) for 2 weeks augmented energy expenditure by 22 % through the induction of plasma serotonin, a neurotransmitter that modulates energy expenditure and mRNA expressions of lipid metabolism genes in peripheral tissues. Analysis of the gut microbiota showed that FGT reduced the proportion of the phylum Firmicutes in hamsters, which could further contribute to its anti-obesity effects. Collectively, these data demonstrate that FGT decreases plasma TAG levels via multiple mechanisms including inhibition of pancreatic lipase, augmentation of energy expenditure, induction of serotonin secretion and alteration of gut microbiota. These results suggest that FGT may be a useful natural agent for preventing hypertriglyceridaemia and obesity.

First Authors:
Dae-Bang Seo,Hyun Woo Jeong,Yeon-Ji Kim

Correspondence Authors:
Sung-Joon Lee

All Authors:
Dae-Bang Seo,Hyun Woo Jeong,Yeon-Ji Kim,Sukyung Kim,Jeongkee Kim,Ji Hae Lee,Kyungmi Joo,Jin Kyu Choi,Song Seok Shin,Sung-Joon Lee