动物:高原青稞的降脂减肥潜力

创作:女巫 审核:JIAN 剑 07月11日
72只雄性Sprague-Dawley大鼠分成4组,喂养正常对照饮食、高脂饮食(HFD)、含有低剂量或高剂量全谷类高原青稞(WHLB)的HFD。
高剂量WHLB显著降低HFD大鼠肝脏和腹部脂肪,以及血浆和肝脏的脂质水平。
WHLB的脂质调节作用伴随着小肠内容物和粪便中胆汁酸的大量排泄。
高剂量WHLB显著增强AMPKα、CYP7A1,、LDLR、LXR和PPARα的肝脏表达,降低HMG-CoAr的表达,增强了回肠中法尼醇X受体的表达,导致顶端依赖钠的胆汁酸转运体表达下降。
延伸阅读

Hypocholesterolaemic effect of whole-grain highland hull-less barley in rats fed a high-fat diet

全谷类高原青稞对高脂饮食饲养大鼠的降血脂作用

05-01, Article, 10.1017/S0007114518000831more

Abstract:
Whole-grain highland hull-less barley (WHLB) contains high amounts of bioactive compounds that potentially exhibit cholesterol-lowering effects. This study investigated the hypocholesterolaemic effect of WHLB. A total of seventy-two male Sprague-Dawley rats were divided into four groups and were fed with the normal control diet, high-fat diet (HFD) and HFD containing low or high dose (10 or 48·95 %) of WHLB. High dose of WHLB significantly decreased the organ indexes of liver and abdominal fat and lipid levels of plasma and liver in HFD rats. The lipid regulation effect of WHLB, which was reconfirmed through hepatocyte morphologic observation, was accompanied by a large excretion of bile acids in the small intestinal contents and the faeces. Real-time PCR analyses, which were further reconfirmed through Western blot analyses, revealed that a high dose of WHLB significantly enhanced the hepatic expressions of AMP-activated protein kinase α, cholesterol 7α-hydroxylase, LDL receptor, liver X receptor, and PPARα and decreased the expression of 3-hydroxy-3-methylglutaryl coenzyme A reductase. It also enhanced the ileal expression of farnesoid X receptor and resulted in the decrease of expression of apical sodium-dependent bile acid transporter. WHLB exhibited hypocholesterolaemic effects mainly by inhibiting cholesterol synthesis, cholesterol accumulation in peripheral tissue, and bile acid reabsorption and by stimulating bile acid synthesis.

First Authors:
Xuejuan Xia

Correspondence Authors:
Jianquan Kan

All Authors:
Xuejuan Xia,Guannan Li,Jiaxin Song,Jiong Zheng,Jianquan Kan