癌症免疫治疗新材料:介孔氧化硅
创作:Laura 审核:照丽 2018年11月29日
  • 用于癌症免疫治疗的介孔氧化硅材料包括可被抗原递呈细胞(APC)吸收的介孔氧化硅纳米颗粒(MSN),和形成3D空间招募APC的微米级介孔氧化硅棒(MSR);
  • 两种疫苗系统都成功激活了获得性免疫反应以消除癌症;
  • 描述了不同介孔氧化硅材料的细胞吸收、生物降解、毒性、生物分布和排泄特性;
  • 综述了MSN作为癌症疫苗佐剂、作为癌症疫苗运载抗原和PAMP、及用于联合治疗的进展;
  • 综述了MSR骨架作为癌症疫苗和体外T细胞扩大培养的应用。
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照丽
本文综述了用于癌症免疫治疗的介孔氧化硅的生物特性,并综述了两种结构的颗粒在癌症免疫治疗中的应用及研究进展。
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Advanced Materials [IF:25.809]

Mesoporous Silica as a Versatile Platform for Cancer Immunotherapy

介孔氧化硅作为癌症免疫治疗的多功能平台

10.1002/adma.201803953

2018-11-12, Report

Abstract & Authors:展开

Abstract:收起
Immunotherapy has been recognized for decades as a promising therapeutic method for cancer treatment. To enhance host immune responses against cancer, antigen-presenting cells (APCs; e.g., dendritic cells) or T cells are educated using immunomodulatory agents including tumor-associated antigens and adjuvants, and manipulated to induce a cascading adaptive immune response targeting tumor cells. Mesoporous silica materials are promising candidates to improve cancer immunotherapy based on their attractive properties that include high porosity, high biocompatibility, facile surface modification, and self-adjuvanticity. Here, the recent progress on mesoporous-silica-based immunotherapies based on two material forms is summarized: 1) mesoporous silica nanoparticles (MSNs), which can be internalized into APCs, and 2) micrometer-sized mesoporous silica rods (MSRs) that can form a 3D space to recruit APCs. Subcutaneously injected MSN-based cancer vaccines can be taken up by peripheral APCs or by APCs in lymphoid organs to educate the immune system against cancer cells. MSR cancer vaccines can recruit immune cells into the MSR scaffold to induce cancer-specific immunity. Both vaccine systems successfully stimulate the adaptive immune response to eradicate cancer in vivo. Thus, mesoporous silica has potential value as a material platform for the treatment of cancer or infectious diseases.

First Authors:
Thanh Loc Nguyen

Correspondence Authors:
Jaeyun Kim

All Authors:
Thanh Loc Nguyen,Youngjin Choi,Jaeyun Kim

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