胃肠道内的NADPH氧化酶和ROS信号(综述)

创作:吴芹 审核:沈志勋 01月11日
活性氧(ROS)在宿主防御和氧化还原信号中是不可或缺的,但又参与炎症或退行性疾病;
NADPH氧化酶是唯一专门用于生成ROS的酶,其通过ROS参与体内平衡、感染性疾病和肠道炎症中肠道屏障的调节;
与极早发炎症性肠病相关的基因中有多个属于NADPH氧化酶家族或是其相关蛋白;
吞噬细胞产生的ROS有抑制病原体入侵的作用,肠道上皮细胞产生的ROS促进宿主-菌群互作及组织修复;
NADPH氧化酶可通过调节H2O2浓度以影响菌群结构。
延伸阅读
Mucosal Immunology [IF:7.352]

NADPH oxidases and ROS signaling in the gastrointestinal tract

胃肠道内的NADPH氧化酶和ROS信号

2018-05-09, Review, 10.1038/s41385-018-0021-8more

Abstract:
Reactive oxygen species (ROS), initially categorized as toxic by-products of aerobic metabolism, have often been called a double-edged sword. ROS are considered indispensable when host defense and redox signaling is concerned and a threat in inflammatory or degenerative diseases. This generalization does not take in account the diversity of oxygen metabolites being generated, their physicochemical characteristics and their production by distinct enzymes in space and time. NOX/DUOX NADPH oxidases are the only enzymes solely dedicated to ROS production and the prime ROS producer for intracellular and intercellular communication due to their widespread expression and intricate regulation. Here we discuss new insights of how NADPH oxidases act via ROS as multifaceted regulators of the intestinal barrier in homeostasis, infectious disease and intestinal inflammation. A closer look at monogenic VEOIBD and commensals as ROS source supports the view of HO as key beneficial messenger in the barrier ecosystem.

First Authors:
Gabriella Aviello

Correspondence Authors:
Ulla G Knaus

All Authors:
Gabriella Aviello,Ulla G Knaus