儿童IBD,与学业压力有关吗?
  • 季节是否影响儿童炎症性肠病(IBD)的发病机理尚无研究论证。
  • 研究通过09-15年间169例儿童IBD患者的记录,以及对122名受试者的观察,研究症状发作与月份的关联。
  • 在怀孕、生育和疾病发作方面没有季节性规律;但发病症状的节奏与学期相关。
  • 研究发现与其他月份相比,IBDS症状在学期开始(8月、9月、1月)和学期结束(12月、5月)显著增加。
  • 推测学业压力可能导致儿童IBD的发病。
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Academic Stress May Contribute to the Onset of Pediatric Inflammatory Bowel Diseases

学业压力可能导致小儿炎症性肠病的发病

10.1097/MPG.0000000000002032

2018-05-30, Article

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It is currently unclear whether seasonality affects the onset of inflammatory bowel diseases (IBDs: Crohn's disease and ulcerative colitis) in children. Here, we examined the records of pediatric IBD patients diagnosed between 2009 and 2015 in a discovery cohort of 169 cases and a validation cohort of 122 subjects, where the month of symptoms onset could be determined. No seasonal patterns could be identified in respect to conception, birth and disease onset. An annual rhythm of symptomatic onset, however, correlating with academic semesters was identified. IBD symptoms in the discovery cohort presented significantly more (p = 0.0218) during 5 months including the initiation (August, September, January) and the termination of academic semesters (December, May) compared to any other 5 months of the year. This observation was validated in the independent cohort (p < 0.0001). Our findings imply that academic stress may contribute to disease onset in pediatric IBD, which may improve timely diagnosis.

First Authors:
Mahesh Z Krishna

Correspondence Authors:
Richard Kellermayer

All Authors:
Mahesh Z Krishna,Keisha R Barton,Carla M Perez,Seema M Walsh,Amit Assa,Richard Kellermayer

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