赵立平团队:全麦+中药+益生元,改善肠道菌群和代谢

肠道菌群代谢障碍产生内毒素引起的慢性炎症可导致肥胖相关的代谢紊乱。
全麦、传统中药及益生元组成的WTP食谱可以满足营养需要并平衡肠道菌群。
93位肥胖志愿者完成了WTP食谱的临床实验,体重明显减轻并改善了胰岛素敏感性、血脂及血压。
粪便样本分析表明产内毒素细菌减少而益生菌增加。
延伸阅读

A gut microbiota-targeted dietary intervention for amelioration of chronic inflammation underlying metabolic syndrome

靶向肠道菌群的干预治疗可改善慢性炎症基础代谢综合征

2013-10-21, Article, 10.1111/1574-6941.12228more

Abstract:
Chronic inflammation induced by endotoxin from a dysbiotic gut microbiota contributes to the development of obesity-related metabolic disorders. Modification of gut microbiota by a diet to balance its composition becomes a promising strategy to help manage obesity. A dietary scheme based on whole grains, traditional Chinese medicinal foods, and prebiotics (WTP diet) was designed to meet human nutritional needs as well as balance the gut microbiota. Ninety-three of 123 central obese volunteers (BMI ≥ 28 kg m(-2) ) completed a self-controlled clinical trial consisting of 9-week intervention on WTP diet followed by a 14-week maintenance period. The average weight loss reached 5.79 ± 4.64 kg (6.62 ± 4.94%), in addition to improvement in insulin sensitivity, lipid profiles, and blood pressure. Pyrosequencing of fecal samples showed that phylotypes related to endotoxin-producing opportunistic pathogens of Enterobacteriaceae and Desulfovibrionaceae were reduced significantly, while those related to gut barrier-protecting bacteria of Bifidobacteriaceae increased. Gut permeability, measured as lactulose/mannitol ratio, was decreased compared with the baseline. Plasma endotoxin load as lipopolysaccharide-binding protein was also significantly reduced, with concomitant decrease in tumor necrosis factor-α, interleukin-6, and an increase in adiponectin. These results suggest that modulation of the gut microbiota via dietary intervention may enhance the intestinal barrier integrity, reduce circulating antigen load, and ultimately ameliorate the inflammation and metabolic phenotypes.

First Authors:
Shuiming Xiao

Correspondence Authors:
Liping Zhao

All Authors:
Shuiming Xiao,Na Fei,Xiaoyan Pang,Jian Shen,Linghua Wang,Baorang Zhang,Menghui Zhang,Xiaojun Zhang,Chenhong Zhang,Min Li,Lifeng Sun,Zhengsheng Xue,Jingjing Wang,Jie Feng,Feiyan Yan,Naisi Zhao,Jiaqi Liu,Wenmin Long,Liping Zhao